HIDE1_HUMAN
ID HIDE1_HUMAN Reviewed; 230 AA.
AC A8MVS5; B2RXI3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Protein HIDE1;
DE Flags: Precursor;
GN Name=HIDE1; Synonyms=C19orf38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A8MVS5; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-12168227, EBI-11959885;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; AC007565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84154.1; -; Genomic_DNA.
DR EMBL; BC157863; AAI57864.1; -; mRNA.
DR CCDS; CCDS45970.1; -.
DR RefSeq; NP_001129954.1; NM_001136482.1.
DR RefSeq; XP_005259903.1; XM_005259846.4.
DR RefSeq; XP_005259904.1; XM_005259847.4.
DR AlphaFoldDB; A8MVS5; -.
DR BioGRID; 129122; 102.
DR IntAct; A8MVS5; 1.
DR STRING; 9606.ENSP00000380920; -.
DR GlyGen; A8MVS5; 3 sites.
DR iPTMnet; A8MVS5; -.
DR PhosphoSitePlus; A8MVS5; -.
DR BioMuta; C19orf38; -.
DR jPOST; A8MVS5; -.
DR MassIVE; A8MVS5; -.
DR MaxQB; A8MVS5; -.
DR PaxDb; A8MVS5; -.
DR PeptideAtlas; A8MVS5; -.
DR PRIDE; A8MVS5; -.
DR ProteomicsDB; 2201; -.
DR Antibodypedia; 25577; 80 antibodies from 16 providers.
DR DNASU; 255809; -.
DR Ensembl; ENST00000397820.5; ENSP00000380920.3; ENSG00000214212.9.
DR Ensembl; ENST00000592854.5; ENSP00000468568.1; ENSG00000214212.9.
DR GeneID; 255809; -.
DR KEGG; hsa:255809; -.
DR MANE-Select; ENST00000397820.5; ENSP00000380920.3; NM_001136482.3; NP_001129954.1.
DR UCSC; uc010dxm.2; human.
DR CTD; 255809; -.
DR GeneCards; C19orf38; -.
DR HGNC; HGNC:34073; C19orf38.
DR HPA; ENSG00000214212; Tissue enriched (bone).
DR neXtProt; NX_A8MVS5; -.
DR OpenTargets; ENSG00000214212; -.
DR PharmGKB; PA162378624; -.
DR VEuPathDB; HostDB:ENSG00000214212; -.
DR eggNOG; ENOG502S4F6; Eukaryota.
DR GeneTree; ENSGT00390000008862; -.
DR HOGENOM; CLU_088804_0_0_1; -.
DR InParanoid; A8MVS5; -.
DR OMA; TDMTFDN; -.
DR OrthoDB; 1400769at2759; -.
DR PhylomeDB; A8MVS5; -.
DR PathwayCommons; A8MVS5; -.
DR SignaLink; A8MVS5; -.
DR BioGRID-ORCS; 255809; 17 hits in 1061 CRISPR screens.
DR ChiTaRS; C19orf38; human.
DR GenomeRNAi; 255809; -.
DR Pharos; A8MVS5; Tdark.
DR PRO; PR:A8MVS5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A8MVS5; protein.
DR Bgee; ENSG00000214212; Expressed in monocyte and 97 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR041066; C19orf38_Ig.
DR InterPro; IPR040438; HIDE1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR36859; PTHR36859; 1.
DR Pfam; PF17737; Ig_C19orf38; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..230
FT /note="Protein HIDE1"
FT /id="PRO_0000341217"
FT TOPO_DOM 20..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..230
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 186..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 230 AA; 24753 MW; F11C80C478E04DC0 CRC64;
MPWTILLFAA GSLAIPAPSI RLVPPYPSSQ EDPIHIACMA PGNFPGANFT LYRGGQVVQL
LQAPTDQRGV TFNLSGGSSK APGGPFHCQY GVLGELNQSQ LSDLSEPVNV SFPVPTWILV
LSLSLAGALF LLAGLVAVAL VVRKVKLRNL QKKRDRESCW AQINFDSTDM SFDNSLFTVS
AKTMPEEDPA TLDDHSGTTA TPSNSRTRKR PTSTSSSPET PEFSTFRACQ
