ID   HIFA1_HAEIF             Reviewed;         216 AA.
AC   Q03846;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Major fimbrial subunit;
DE   AltName: Full=Major pilin;
DE   Flags: Precursor;
GN   Name=hifA;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Eagan / Serotype B;
RX   PubMed=2037360; DOI=10.1128/iai.59.6.1991-1996.1991;
RA   Forney L.J., Marrs C.F., Bektesh S., Gilsdorf J.R.;
RT   "Comparison and analysis of the nucleotide sequences of pilin genes from
RT   Haemophilus influenzae type b strains Eagan and M43.";
RL   Infect. Immun. 59:1991-1996(1991).
CC   -!- FUNCTION: Mediates adherence to oropharyngeal epithelial cells. Helps
CC       the airway colonization process.
CC   -!- SUBCELLULAR LOCATION: Fimbrium.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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DR   EMBL; M64334; AAA24965.1; -; Genomic_DNA.
DR   PIR; A39021; A39021.
DR   PIR; A60331; A60331.
DR   AlphaFoldDB; Q03846; -.
DR   SMR; Q03846; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   Pfam; PF00419; Fimbrial; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fimbrium; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..216
FT                   /note="Major fimbrial subunit"
FT                   /id="PRO_0000009216"
FT   DISULFID        41..81
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   216 AA;  23266 MW;  1BE1D3B5978F8FE0 CRC64;
     MKKTLLGSLI LLAFAGNVQA AANADTKGTV TFFGKVVENT CQVKTDHKNR SVVLNDVGKN
     SLKDKGNTAM PTPFTITLQN CNLTAANSST NKANKVGLYF YSWENADKEN NFTLKNKTST
     SNDFATMVNI QLMESDGTKE IKVVGKETED FVHKNATGAG VALTQTHPDN DHISGSTQLT
     GVTGDLPLHF IAQYYSLGST TAGKVQSSVD FQIAYE