ID   HIFA2_HAEIF             Reviewed;         213 AA.
AC   P14212;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Major fimbrial subunit;
DE   AltName: Full=Major pilin;
DE   Flags: Precursor;
GN   Name=hifA;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 21-36.
RC   STRAIN=AM30 (770235) / Serotype B;
RX   PubMed=2573518;
RA   van Ham S.M., Mooi F.R., Sindhunata M.G., Maris W.R., van Alphen L.;
RT   "Cloning and expression in Escherichia coli of Haemophilus influenzae
RT   fimbrial genes establishes adherence to oropharyngeal epithelial cells.";
RL   EMBO J. 8:3535-3540(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AM30 (770235) / Serotype B;
RX   PubMed=7997179; DOI=10.1111/j.1365-2958.1994.tb00461.x;
RA   van Ham M.S., van Alphen L., Mooi F.R., van Putten J.P.M.;
RT   "The fimbrial gene cluster of Haemophilus influenzae type b.";
RL   Mol. Microbiol. 13:673-684(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1595 / Biotype IV;
RX   PubMed=11598076; DOI=10.1128/iai.69.11.7010-7019.2001;
RA   Clemans D.L., Marrs C.F., Bauer R.J., Patel M., Gilsdorf J.R.;
RT   "Analysis of pilus adhesins from Haemophilus influenzae biotype IV
RT   strains.";
RL   Infect. Immun. 69:7010-7019(2001).
CC   -!- FUNCTION: Mediates adherence to oropharyngeal epithelial cells. Helps
CC       the airway colonization process.
CC   -!- SUBCELLULAR LOCATION: Fimbrium.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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DR   EMBL; X16991; CAA34859.1; -; Genomic_DNA.
DR   EMBL; Z33502; CAA83905.1; -; Genomic_DNA.
DR   EMBL; AY034824; AAK62564.1; -; Genomic_DNA.
DR   PIR; S06788; S06788.
DR   AlphaFoldDB; P14212; -.
DR   SMR; P14212; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   Pfam; PF00419; Fimbrial; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Fimbrium; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000269|PubMed:2573518"
FT   CHAIN           21..213
FT                   /note="Major fimbrial subunit"
FT                   /id="PRO_0000009217"
FT   DISULFID        41..81
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   213 AA;  23161 MW;  19679E00808DC609 CRC64;
     MKKTLLGSLI LLAFAGNVQA DINTETSGKV TFFGKVVENT CKVKTEHKNL SVVLNDVGKN
     SLSTKVNTAM PTPFTITLQN CDPTTANGTA NKANKVGLYF YSWKNVDKEN NFTLKNEQTT
     ADYATNVNIQ LMESNGTKAI SVVGKETEDF MHTNNNGVAL NQTHPNNAHI SGSTQLTTGT
     NELPLHFIAQ YYATNKATAG KVQSSVDFQI AYE