ID   HIFA4_HAEIF             Reviewed;         213 AA.
AC   P45989;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Major fimbrial subunit;
DE   AltName: Full=Major pilin;
DE   Flags: Precursor;
GN   Name=hifA;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=86-1249 / LKP serotype 4;
RA   Green B.A., Olmsted S.B., Novitsky B.K.;
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates adherence to oropharyngeal epithelial cells. Helps
CC       the airway colonization process.
CC   -!- SUBCELLULAR LOCATION: Fimbrium.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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DR   EMBL; U19761; AAA61910.1; -; Genomic_DNA.
DR   AlphaFoldDB; P45989; -.
DR   SMR; P45989; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   Pfam; PF00419; Fimbrial; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fimbrium; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..213
FT                   /note="Major fimbrial subunit"
FT                   /id="PRO_0000009219"
FT   DISULFID        41..81
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   213 AA;  23191 MW;  03D79E00809CC609 CRC64;
     MKKTLLGSLI LLAFAGNVQA DINTETSGKV TFFGKVVENT CKVKTEHKNL SVVLNDVGKN
     SLSTKVNTAM PTPFTITLQN CDPTTANGTA NKANKVGLYF YSWKNVDKEN NFTLKNEQTT
     ADYATNVNIQ LMESNGTKAI SVVGKETEDF MHTNNNGVAL NQTHPNNTHI SGSTQLTTGT
     NELPLHFIAQ YYATNKATAG KVQSSVDFQI AYE