ID   HIFA5_HAEIF             Reviewed;         211 AA.
AC   P45990;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Major fimbrial subunit;
DE   AltName: Full=Major pilin;
DE   Flags: Precursor;
GN   Name=hifA;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=81-0384 / LKP serotype 5;
RA   Green B.A., Olmsted S.B., Novitsky B.K.;
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates adherence to oropharyngeal epithelial cells. Helps
CC       the airway colonization process.
CC   -!- SUBCELLULAR LOCATION: Fimbrium.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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DR   EMBL; U19795; AAA61764.1; -; Genomic_DNA.
DR   AlphaFoldDB; P45990; -.
DR   SMR; P45990; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   Pfam; PF00419; Fimbrial; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fimbrium; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..211
FT                   /note="Major fimbrial subunit"
FT                   /id="PRO_0000009220"
FT   DISULFID        43..83
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   211 AA;  22527 MW;  CF17049A135626D2 CRC64;
     MKKTLLGSLI LLAFAGNVQA ADNPNPETKG KVTFYGKVVE NTCKVKSGNR DMSVVLNDVG
     KAHLSQKGYT AMPTPFTITL EGCNANTGTK PKANKVGVYF YSWNNADKEN SYTLKSTLTG
     TDKADNVNIQ IFQENGTDAI GVADKTIDDF THKNNGSTNS DKPTKNHISS ATALNNQTGD
     IALHYIAQYY ATGMASAGKG PTSVDFPIAY G