ID   HIFC1_HAEIF             Reviewed;         837 AA.
AC   P33397;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Outer membrane usher protein HifC;
DE   Flags: Precursor;
GN   Name=hifC;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Eagan / Serotype B;
RX   PubMed=7905461; DOI=10.1128/iai.62.2.468-475.1994;
RA   Watson W.J., Gilsdorf J.R., Tucci M.A., McCrea K.W., Forney L.J.,
RA   Marrs C.F.;
RT   "Identification of a gene essential for piliation in Haemophilus influenzae
RT   type b with homology to the pilus assembly platform genes of Gram-negative
RT   bacteria.";
RL   Infect. Immun. 62:468-475(1994).
CC   -!- FUNCTION: Essential for piliation.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-97 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; U02932; AAB53096.1; -; Unassigned_DNA.
DR   AlphaFoldDB; P33397; -.
DR   SMR; P33397; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015473; F:fimbrial usher porin activity; IEA:InterPro.
DR   GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR   Gene3D; 2.60.40.2070; -; 1.
DR   Gene3D; 2.60.40.2610; -; 1.
DR   Gene3D; 3.10.20.410; -; 1.
DR   InterPro; IPR000015; Fimb_usher.
DR   InterPro; IPR018030; Fimbrial_membr_usher_CS.
DR   InterPro; IPR042186; FimD_plug_dom.
DR   InterPro; IPR025949; PapC-like_C.
DR   InterPro; IPR043142; PapC-like_C_sf.
DR   InterPro; IPR025885; PapC_N.
DR   InterPro; IPR037224; PapC_N_sf.
DR   PANTHER; PTHR30451; PTHR30451; 1.
DR   Pfam; PF13953; PapC_C; 1.
DR   Pfam; PF13954; PapC_N; 1.
DR   Pfam; PF00577; Usher; 1.
DR   SUPFAM; SSF141729; SSF141729; 1.
DR   PROSITE; PS01151; FIMBRIAL_USHER; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Fimbrium biogenesis; Membrane; Signal;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..837
FT                   /note="Outer membrane usher protein HifC"
FT                   /id="PRO_0000009316"
FT   DISULFID        813..833
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   837 AA;  92733 MW;  BA529323AF63BF8B CRC64;
     MKTKNFPLNK IAFACTLLLA NPVAWAEDQF DASLWGGGSV LGIDFARFNV KNAVLPGRYE
     AQIYVNNEEK GESDIIFADN PATGRAELCF TPKLQEMLDL MDEAIVKSPN SEDDTCVFAS
     DAIPKGTFDY QGGDMKLKLE IPQALTIRRP RGYIAPSRWQ TGTNAAFANY DINYYRSGNP
     EVKSESLYVG LRGGVNFGNW ALRHNGSFSR FENQSSSGFT DKGKNHYERG DTYLQRDFAL
     LRGNVTVGDF FSTARIGENF GLRGLRIASD DRMLAPSQRG FAPVVRGVAN TNAKVSIKQN
     GYTIYQITVP AGPFVINDLY ASGYSGDLTV EIQESDGKVR SFIVPFSNLA PLMRVGHLRY
     QLAGGRYRID SRTFDERVLQ GVLQYGLTNH LTLNSSLLYT RHYRAGLFGF GLNTPIGAFS
     ADATWSHAEF PLKKVSKNGY SLHGSYSINF NEIGTNLTLA AYRYSSRDFY TLSDTIGLNR
     TFRQFSGAYL PEIYRPKNQF QVSLSQSLGN WGNLYLSGQT YNYWEKRGTN TQYQVAYSNS
     FHILNYSVNL SQSIDKETGK RDNSIYLSLS LPLGDNHSAD SSYSRSGNDI NQRLGVNGSF
     GERHQWSYGI NASRNNQGYR SYDGNLSHNN SIGSYRASYS RDSLKNRSTS LGVSGAVVAH
     KYGITLSQPV GESFAIIHAK DAAGAKVESG ANVSLDYFGN AVVPYTSPYE INYIGINPSD
     AEANVEFEAT ERQIIPRANS ISLVDFRTGK NTMVLFNLTL PNGEPVPMAS TAQDSEGAFV
     GDVVQGGVLF ANKLTQPKGE LIVKWGERES EQCRFHYQVD LDNAQIQNHD IQCKTAE