ID   HIFC2_HAEIF             Reviewed;         837 AA.
AC   P45997;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Outer membrane usher protein HifC;
DE   Flags: Precursor;
GN   Name=hifC;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AM30 (770235) / Serotype B;
RX   PubMed=7997179; DOI=10.1111/j.1365-2958.1994.tb00461.x;
RA   van Ham M.S., van Alphen L., Mooi F.R., van Putten J.P.M.;
RT   "The fimbrial gene cluster of Haemophilus influenzae type b.";
RL   Mol. Microbiol. 13:673-684(1994).
CC   -!- FUNCTION: Essential for piliation.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-97 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; Z33502; CAA83902.1; -; Genomic_DNA.
DR   PIR; S54429; S54429.
DR   AlphaFoldDB; P45997; -.
DR   SMR; P45997; -.
DR   PRIDE; P45997; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015473; F:fimbrial usher porin activity; IEA:InterPro.
DR   GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR   Gene3D; 2.60.40.2070; -; 1.
DR   Gene3D; 2.60.40.2610; -; 1.
DR   Gene3D; 3.10.20.410; -; 1.
DR   InterPro; IPR000015; Fimb_usher.
DR   InterPro; IPR018030; Fimbrial_membr_usher_CS.
DR   InterPro; IPR042186; FimD_plug_dom.
DR   InterPro; IPR025949; PapC-like_C.
DR   InterPro; IPR043142; PapC-like_C_sf.
DR   InterPro; IPR025885; PapC_N.
DR   InterPro; IPR037224; PapC_N_sf.
DR   PANTHER; PTHR30451; PTHR30451; 1.
DR   Pfam; PF13953; PapC_C; 1.
DR   Pfam; PF13954; PapC_N; 1.
DR   Pfam; PF00577; Usher; 1.
DR   SUPFAM; SSF141729; SSF141729; 1.
DR   PROSITE; PS01151; FIMBRIAL_USHER; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Fimbrium biogenesis; Membrane; Signal;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..837
FT                   /note="Outer membrane usher protein HifC"
FT                   /id="PRO_0000009317"
FT   DISULFID        813..833
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   837 AA;  92641 MW;  0992A9F2C71F2774 CRC64;
     MKTKNFPLNK IAFACTLLLA NPVAWAEDQF DASLWGGGSV LGIDFARFNV KNAVLPGRYE
     AQIYVNNEEK GESDIIFADN PATGRAELCF TPKLQEMLDL MDEAIVKSPN AEDDTCVFAS
     EAIPKGTFDY QGGDMKLKLE LPQALTIRRP RGYIAPSRWQ TGTNAASANY DINYYRSGNP
     EVKSKSLYVG LRGGVNLGNW ALRHNGSFSR FENHSSSGFT DKGKNHYERG DTYLQRDFAL
     LRGNVTVGDF FSTARIGESF GLRGLRIASD DRMLAPSQRG FAPVVRGVAN TNAKVSIKQN
     GYTIYQITVP AGPFVINDLY ASGYSGDLTV EIQESDGKVR SFIVPFSNLA PLMRVGHLRY
     QLAGGRYRID SRTFDERVLQ GVLQYGLTNH LTLNSSLLYT RHYRAGLFGF GLNTPIGAFS
     ADATWSHAEF PLKKVSKNGY SLHGSYSINF NEIGTNLTLA AYRYSSRDFY TLSDTIGLNR
     TFKQFSGAYL PEIYRPKNQF QVSLSQSLGN WGNLYLSGQT YNYWEKRGTN TQYQLAYANR
     FHILNYSINL SQSIDKETGK RDNSIYLSLS LPLGDNHSAD SSYSRSGNDI NQRLGVNGSF
     GERHQWSYGI NASRNNQGYR SYDANLAHNN SIGSYRASYS RDSLKNRSTS LGASGAVVAH
     KYGITLSQPV GESFAIIHAK DAAGAKVESG ANVSLDYFGN AVVPYTSPYE INYIGINPSD
     AEANVEFEAT ERQIIPRANS ISLVDFRTGK NTMVLFNLTL PNGEPVPMAS TAQDSEGAFV
     GDVVQGGVLF ANKLTQPKGE LIVKWGERES EQCRFHYQVD LDNAQIQNHD IQCKTAE