HIG1A_PONAB
ID HIG1A_PONAB Reviewed; 93 AA.
AC Q5NVQ1;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=HIG1 domain family member 1A, mitochondrial;
GN Name=HIGD1A;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Proposed subunit of cytochrome c oxidase (COX, complex IV),
CC which is the terminal component of the mitochondrial respiratory chain
CC that catalyzes the reduction of oxygen to water. May play a role in the
CC assembly of respiratory supercomplexes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with cytochrome c oxidase (COX, complex IV);
CC proposed complex component. Also associates with respiratory chain
CC supercomplexes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255|PROSITE-
CC ProRule:PRU00836}. Mitochondrion inner membrane {ECO:0000250}.
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DR EMBL; CR925959; CAI29612.1; -; mRNA.
DR RefSeq; NP_001127074.1; NM_001133602.1.
DR AlphaFoldDB; Q5NVQ1; -.
DR BMRB; Q5NVQ1; -.
DR SMR; Q5NVQ1; -.
DR STRING; 9601.ENSPPYP00000015631; -.
DR Ensembl; ENSPPYT00000016252; ENSPPYP00000015631; ENSPPYG00000013974.
DR GeneID; 100174104; -.
DR KEGG; pon:100174104; -.
DR CTD; 25994; -.
DR eggNOG; KOG4431; Eukaryota.
DR GeneTree; ENSGT00940000154276; -.
DR HOGENOM; CLU_153308_2_0_1; -.
DR InParanoid; Q5NVQ1; -.
DR OMA; DESHTNK; -.
DR OrthoDB; 1581485at2759; -.
DR TreeFam; TF314628; -.
DR Proteomes; UP000001595; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR InterPro; IPR007667; Hypoxia_induced_domain.
DR Pfam; PF04588; HIG_1_N; 1.
DR PROSITE; PS51503; HIG1; 1.
PE 3: Inferred from homology;
KW Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Phosphoprotein; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9Y241"
FT CHAIN 2..93
FT /note="HIG1 domain family member 1A, mitochondrial"
FT /id="PRO_0000215772"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT DOMAIN 2..93
FT /note="HIG1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y241"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8VH49"
SQ SEQUENCE 93 AA; 10143 MW; 9399D8D1D381B66B CRC64;
MSTDTGVSLP SYEEDQGSKL IRKAKEAPFV PVGIAGFAAI VAYGLYKLKS RGNTKMSIHL
IHMRVAAQGF VVGAMTVGMG YSMYREFWAK PKP
