HIG1A_RAT
ID HIG1A_RAT Reviewed; 93 AA.
AC Q8VH49; Q6PCV5;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=HIG1 domain family member 1A, mitochondrial;
DE AltName: Full=Hypoxia-inducible gene 1 protein;
GN Name=Higd1a; Synonyms=Hig1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Spinal cord;
RX PubMed=15968589; DOI=10.1387/ijdb.041901gb;
RA Bedo G.R., Vargas M., Ferreiro M.J., Chalar C., Agrati D.;
RT "Characterization of hypoxia induced gene 1: expression during rat central
RT nervous system maturation and evidence of antisense RNA expression.";
RL Int. J. Dev. Biol. 49:431-436(2005).
RN [2]
RP SEQUENCE REVISION TO 8.
RC STRAIN=Sprague-Dawley; TISSUE=Spinal cord;
RA Vargas M., Bedo G.;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Proposed subunit of cytochrome c oxidase (COX, complex IV),
CC which is the terminal component of the mitochondrial respiratory chain
CC that catalyzes the reduction of oxygen to water. May play a role in the
CC assembly of respiratory supercomplexes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with cytochrome c oxidase (COX, complex IV);
CC proposed complex component. Also associates with respiratory chain
CC supercomplexes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255|PROSITE-
CC ProRule:PRU00836}. Mitochondrion inner membrane {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in brain and spinal cord.
CC {ECO:0000269|PubMed:15968589}.
CC -!- DEVELOPMENTAL STAGE: Expression is increased between P1 and P15 in the
CC spinal cord and a differential spatial pattern. In the P1 spinal cord
CC there is a preferential expression in regions of dorsal laminae II and
CC III and laminae IX ventrally; while in P8, the distribution is more
CC widespread and overall expression is increased.
CC {ECO:0000269|PubMed:15968589}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY062253; AAL38979.2; -; mRNA.
DR EMBL; BC059118; AAH59118.1; -; mRNA.
DR RefSeq; NP_543178.2; NM_080902.4.
DR AlphaFoldDB; Q8VH49; -.
DR SMR; Q8VH49; -.
DR STRING; 10116.ENSRNOP00000061362; -.
DR iPTMnet; Q8VH49; -.
DR PhosphoSitePlus; Q8VH49; -.
DR jPOST; Q8VH49; -.
DR PaxDb; Q8VH49; -.
DR PRIDE; Q8VH49; -.
DR Ensembl; ENSRNOT00000064114; ENSRNOP00000061362; ENSRNOG00000019428.
DR GeneID; 140937; -.
DR KEGG; rno:140937; -.
DR UCSC; RGD:620215; rat.
DR CTD; 25994; -.
DR RGD; 620215; Higd1a.
DR eggNOG; KOG4431; Eukaryota.
DR GeneTree; ENSGT00940000154276; -.
DR HOGENOM; CLU_153308_2_0_1; -.
DR InParanoid; Q8VH49; -.
DR OMA; GYSMAKE; -.
DR OrthoDB; 1581485at2759; -.
DR PhylomeDB; Q8VH49; -.
DR PRO; PR:Q8VH49; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000019428; Expressed in duodenum and 20 other tissues.
DR Genevisible; Q8VH49; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0042149; P:cellular response to glucose starvation; ISO:RGD.
DR GO; GO:0071456; P:cellular response to hypoxia; ISO:RGD.
DR GO; GO:0097250; P:mitochondrial respirasome assembly; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISO:RGD.
DR GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; ISO:RGD.
DR InterPro; IPR007667; Hypoxia_induced_domain.
DR Pfam; PF04588; HIG_1_N; 1.
DR PROSITE; PS51503; HIG1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Phosphoprotein; Reference proteome;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9Y241"
FT CHAIN 2..93
FT /note="HIG1 domain family member 1A, mitochondrial"
FT /id="PRO_0000215773"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT TOPO_DOM 90..93
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT DOMAIN 2..93
FT /note="HIG1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y241"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 93 AA; 10301 MW; 27E879D784C0A8C9 CRC64;
MSTNTDLSLS SYDEGQGSKF IRKARETPFV PIGMAGFAAI VAYGLYKLKS RGNTKMSIHL
IHMRVAAQGF VVGAMTLGMG YSMYQEFWAK RKP
