HIG1B_MOUSE
ID HIG1B_MOUSE Reviewed; 98 AA.
AC Q99JY6; Q8C1M5;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=HIG1 domain family member 1B;
GN Name=Higd1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00836};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836}.
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DR EMBL; AK009942; BAC25277.1; -; mRNA.
DR EMBL; BC005568; AAH05568.1; -; mRNA.
DR CCDS; CCDS36345.1; -.
DR RefSeq; NP_543122.1; NM_080846.1.
DR RefSeq; XP_006534460.1; XM_006534397.3.
DR AlphaFoldDB; Q99JY6; -.
DR SMR; Q99JY6; -.
DR STRING; 10090.ENSMUSP00000021302; -.
DR PhosphoSitePlus; Q99JY6; -.
DR MaxQB; Q99JY6; -.
DR PaxDb; Q99JY6; -.
DR PRIDE; Q99JY6; -.
DR Antibodypedia; 63991; 41 antibodies from 10 providers.
DR Ensembl; ENSMUST00000021302; ENSMUSP00000021302; ENSMUSG00000020928.
DR Ensembl; ENSMUST00000107072; ENSMUSP00000102687; ENSMUSG00000020928.
DR Ensembl; ENSMUST00000107073; ENSMUSP00000102688; ENSMUSG00000020928.
DR GeneID; 75689; -.
DR KEGG; mmu:75689; -.
DR UCSC; uc007lso.1; mouse.
DR CTD; 51751; -.
DR MGI; MGI:1922939; Higd1b.
DR VEuPathDB; HostDB:ENSMUSG00000020928; -.
DR eggNOG; KOG4431; Eukaryota.
DR GeneTree; ENSGT00940000161778; -.
DR HOGENOM; CLU_153308_2_0_1; -.
DR InParanoid; Q99JY6; -.
DR OMA; GPTKMSI; -.
DR OrthoDB; 1307900at2759; -.
DR PhylomeDB; Q99JY6; -.
DR TreeFam; TF314628; -.
DR BioGRID-ORCS; 75689; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Higd1b; mouse.
DR PRO; PR:Q99JY6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q99JY6; protein.
DR Bgee; ENSMUSG00000020928; Expressed in interventricular septum and 118 other tissues.
DR Genevisible; Q99JY6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0097250; P:mitochondrial respirasome assembly; IBA:GO_Central.
DR InterPro; IPR007667; Hypoxia_induced_domain.
DR Pfam; PF04588; HIG_1_N; 1.
DR PROSITE; PS51503; HIG1; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..98
FT /note="HIG1 domain family member 1B"
FT /id="PRO_0000215775"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..46
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT TOPO_DOM 47..60
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..83
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT TOPO_DOM 84..98
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 1..94
FT /note="HIG1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT CONFLICT 74
FT /note="G -> R (in Ref. 1; BAC25277)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 98 AA; 10940 MW; 364F81D4997CF1D8 CRC64;
MSANKGWWVP PEGEDNLSKK FLRKTRESPL VPIGVAGCLV IAAYRIYRLK ARGSTKLSIH
LIHTRVAAQA CAVGAIMLGA MYTMYRDYIK RVSEDAEK
