HIG1C_HUMAN
ID HIG1C_HUMAN Reviewed; 97 AA.
AC A8MV81;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=HIG1 domain family member 1C;
GN Name=HIGD1C; Synonyms=UBIE, UBIE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
CC -!- INTERACTION:
CC A8MV81; P02654: APOC1; NbExp=3; IntAct=EBI-12809676, EBI-1220105;
CC A8MV81; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-12809676, EBI-7062247;
CC A8MV81; Q9UHQ9: CYB5R1; NbExp=3; IntAct=EBI-12809676, EBI-953870;
CC A8MV81; O95363: FARS2; NbExp=3; IntAct=EBI-12809676, EBI-2513774;
CC A8MV81; Q05329: GAD2; NbExp=3; IntAct=EBI-12809676, EBI-9304251;
CC A8MV81; Q96E29: MTERF3; NbExp=3; IntAct=EBI-12809676, EBI-7825321;
CC A8MV81; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12809676, EBI-741158;
CC A8MV81; Q96AL5: PBX3; NbExp=3; IntAct=EBI-12809676, EBI-741171;
CC A8MV81; Q8N0V3: RBFA; NbExp=3; IntAct=EBI-12809676, EBI-3232108;
CC A8MV81; Q17RD7: SYT16; NbExp=3; IntAct=EBI-12809676, EBI-10238936;
CC A8MV81; Q15560: TCEA2; NbExp=3; IntAct=EBI-12809676, EBI-710310;
CC A8MV81; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12809676, EBI-8638294;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00836};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836}.
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DR EMBL; AC008121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS44882.1; -.
DR RefSeq; NP_001103089.1; NM_001109619.1.
DR AlphaFoldDB; A8MV81; -.
DR SMR; A8MV81; -.
DR BioGRID; 534793; 17.
DR IntAct; A8MV81; 15.
DR STRING; 9606.ENSP00000381473; -.
DR iPTMnet; A8MV81; -.
DR PhosphoSitePlus; A8MV81; -.
DR BioMuta; HIGD1C; -.
DR jPOST; A8MV81; -.
DR MassIVE; A8MV81; -.
DR MaxQB; A8MV81; -.
DR PaxDb; A8MV81; -.
DR PeptideAtlas; A8MV81; -.
DR PRIDE; A8MV81; -.
DR ProteomicsDB; 2163; -.
DR Antibodypedia; 67248; 42 antibodies from 11 providers.
DR DNASU; 613227; -.
DR Ensembl; ENST00000398455.3; ENSP00000381473.3; ENSG00000214511.3.
DR GeneID; 613227; -.
DR KEGG; hsa:613227; -.
DR UCSC; uc010smw.3; human.
DR CTD; 613227; -.
DR GeneCards; HIGD1C; -.
DR HGNC; HGNC:28044; HIGD1C.
DR HPA; ENSG00000214511; Tissue enhanced (brain).
DR neXtProt; NX_A8MV81; -.
DR OpenTargets; ENSG00000214511; -.
DR PharmGKB; PA142671683; -.
DR VEuPathDB; HostDB:ENSG00000214511; -.
DR eggNOG; KOG4431; Eukaryota.
DR GeneTree; ENSGT00940000162804; -.
DR HOGENOM; CLU_153308_2_0_1; -.
DR InParanoid; A8MV81; -.
DR OMA; RKDQKMS; -.
DR OrthoDB; 1581485at2759; -.
DR PhylomeDB; A8MV81; -.
DR TreeFam; TF314628; -.
DR PathwayCommons; A8MV81; -.
DR SignaLink; A8MV81; -.
DR BioGRID-ORCS; 613227; 13 hits in 1030 CRISPR screens.
DR ChiTaRS; HIGD1C; human.
DR GenomeRNAi; 613227; -.
DR Pharos; A8MV81; Tdark.
DR PRO; PR:A8MV81; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A8MV81; protein.
DR Bgee; ENSG00000214511; Expressed in corpus callosum and 82 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0097250; P:mitochondrial respirasome assembly; IBA:GO_Central.
DR InterPro; IPR007667; Hypoxia_induced_domain.
DR Pfam; PF04588; HIG_1_N; 1.
DR PROSITE; PS51503; HIG1; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..97
FT /note="HIG1 domain family member 1C"
FT /id="PRO_0000342673"
FT TOPO_DOM 1..26
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT TOPO_DOM 48..58
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT TOPO_DOM 80..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 1..92
FT /note="HIG1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
SQ SEQUENCE 97 AA; 11079 MW; BB5185D0DABF9A9A CRC64;
MSSDNQWSAD EDEGQLSRLI RKSRDSPFVP IGIAGFVTVV SCGLYKLKYR RDQKMSIHLI
HMRVAAQGFV VGAVTLGVLY SMYKDYIRPR FFSESKK
