ID   HIG1C_MOUSE             Reviewed;          96 AA.
AC   Q76I25;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=HIG1 domain family member 1C;
GN   Name=Higd1c; Synonyms=Gm921, Hig1-4, Ubie;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Abe S.;
RT   "Mus musculus cDNA for UbiE-YGHL1 intergenic splicing product, complete
RT   CDS.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00836};
CC       Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836}.
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DR   EMBL; AB099517; BAD06947.1; -; mRNA.
DR   CCDS; CCDS37210.1; -.
DR   RefSeq; NP_001002900.1; NM_001002900.1.
DR   AlphaFoldDB; Q76I25; -.
DR   SMR; Q76I25; -.
DR   STRING; 10090.ENSMUSP00000075098; -.
DR   PhosphoSitePlus; Q76I25; -.
DR   PaxDb; Q76I25; -.
DR   PRIDE; Q76I25; -.
DR   Antibodypedia; 67248; 42 antibodies from 11 providers.
DR   Ensembl; ENSMUST00000175683; ENSMUSP00000134927; ENSMUSG00000093550.
DR   Ensembl; ENSMUST00000177211; ENSMUSP00000134848; ENSMUSG00000093550.
DR   GeneID; 380975; -.
DR   KEGG; mmu:380975; -.
DR   UCSC; uc007xrb.1; mouse.
DR   CTD; 613227; -.
DR   MGI; MGI:2685767; Higd1c.
DR   VEuPathDB; HostDB:ENSMUSG00000093550; -.
DR   eggNOG; KOG4431; Eukaryota.
DR   GeneTree; ENSGT00940000162804; -.
DR   HOGENOM; CLU_153308_2_0_1; -.
DR   InParanoid; Q76I25; -.
DR   OMA; LARENWN; -.
DR   OrthoDB; 1178802at2759; -.
DR   PhylomeDB; Q76I25; -.
DR   TreeFam; TF314628; -.
DR   BioGRID-ORCS; 380975; 0 hits in 35 CRISPR screens.
DR   PRO; PR:Q76I25; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q76I25; protein.
DR   Bgee; ENSMUSG00000093550; Expressed in proximal tubule and 15 other tissues.
DR   ExpressionAtlas; Q76I25; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0097250; P:mitochondrial respirasome assembly; IBA:GO_Central.
DR   InterPro; IPR007667; Hypoxia_induced_domain.
DR   Pfam; PF04588; HIG_1_N; 1.
DR   PROSITE; PS51503; HIG1; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..96
FT                   /note="HIG1 domain family member 1C"
FT                   /id="PRO_0000215776"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT   TOPO_DOM        45..58
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT   TOPO_DOM        82..96
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..91
FT                   /note="HIG1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
SQ   SEQUENCE   96 AA;  10825 MW;  BC2BAF9D9E5EF911 CRC64;
     MSSDEWSAAE DEGQLSRLLR KSRDSPFVPV GMAGFVAVLS YGLYKLNSRR EQKMSLHLIH
     VRVAAQGCVV GAVTLGVLYS MYKDYIRPRF FNVPKK