ID   HIG2B_HUMAN             Reviewed;         106 AA.
AC   Q4VC39;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Putative HIG1 domain family member 2B;
DE   AltName: Full=HIG1 domain family member 2B pseudogene;
GN   Name=HIGD2B; Synonyms=HIGD2BP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q4VC39; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-12881610, EBI-347538;
CC       Q4VC39; Q12837: POU4F2; NbExp=3; IntAct=EBI-12881610, EBI-17236143;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00836};
CC       Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00836}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; CH471082; EAW77911.1; -; Genomic_DNA.
DR   EMBL; BC040890; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS86473.1; -.
DR   AlphaFoldDB; Q4VC39; -.
DR   IntAct; Q4VC39; 2.
DR   STRING; 9606.ENSP00000307951; -.
DR   BioMuta; HIGD2B; -.
DR   DMDM; 74753804; -.
DR   PaxDb; Q4VC39; -.
DR   PRIDE; Q4VC39; -.
DR   Antibodypedia; 7424; 9 antibodies from 5 providers.
DR   Ensembl; ENST00000311755.6; ENSP00000307951.3; ENSG00000175202.6.
DR   MANE-Select; ENST00000311755.6; ENSP00000307951.3; NM_001350932.3; NP_001337861.1.
DR   UCSC; uc059lck.1; human.
DR   GeneCards; HIGD2B; -.
DR   HGNC; HGNC:26984; HIGD2B.
DR   HPA; ENSG00000175202; Tissue enriched (testis).
DR   neXtProt; NX_Q4VC39; -.
DR   VEuPathDB; HostDB:ENSG00000175202; -.
DR   eggNOG; KOG4431; Eukaryota.
DR   GeneTree; ENSGT00910000144291; -.
DR   HOGENOM; CLU_087356_4_0_1; -.
DR   InParanoid; Q4VC39; -.
DR   OMA; FPMETGW; -.
DR   PhylomeDB; Q4VC39; -.
DR   TreeFam; TF314628; -.
DR   PathwayCommons; Q4VC39; -.
DR   SignaLink; Q4VC39; -.
DR   Pharos; Q4VC39; Tdark.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q4VC39; protein.
DR   Bgee; ENSG00000175202; Expressed in testis and 8 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0097250; P:mitochondrial respirasome assembly; IBA:GO_Central.
DR   InterPro; IPR007667; Hypoxia_induced_domain.
DR   Pfam; PF04588; HIG_1_N; 1.
DR   PROSITE; PS51503; HIG1; 1.
PE   5: Uncertain;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..106
FT                   /note="Putative HIG1 domain family member 2B"
FT                   /id="PRO_0000344213"
FT   TOPO_DOM        1..46
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT   TOPO_DOM        68..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT   TOPO_DOM        103..106
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..106
FT                   /note="HIG1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
SQ   SEQUENCE   106 AA;  11405 MW;  E930373245708767 CRC64;
     MATLGFVTPE APFESSKPPI FEGLSPTVYS NPEGFKEKFL RKTRENPVVP IGFLCTAAVL
     TNGLYCFHQG NSQCSRLMMH TQIAAQGFTI AAILLGLAAT AMKSPP