ID   HIGB1_MYCTO             Reviewed;         125 AA.
AC   P9WJA4; L0T8D1; P95259; Q7D7P9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Probable endoribonuclease HigB1 {ECO:0000305};
DE            EC=3.1.-.-;
DE   AltName: Full=Toxin HigB {ECO:0000305};
GN   Name=higB1 {ECO:0000305}; OrderedLocusNames=MT2004;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Toxic component of an atypical, type II toxin-antitoxin
CC       chaperone (TAC) system. Probably an endoribonuclease, neutralized by
CC       its cognate antitoxin HigA which also requires SecB-like chaperone
CC       MT2006 (AC Q7D7P7). {ECO:0000250|UniProtKB:P9WJA5}.
CC   -!- INDUCTION: Operon autorepressed by HigA1.
CC       {ECO:0000250|UniProtKB:P9WJA5}.
CC   -!- SIMILARITY: Belongs to the mycobacterial HigB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46276.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK46276.1; ALT_INIT; Genomic_DNA.
DR   PIR; G70638; G70638.
DR   RefSeq; WP_010886136.1; NC_002755.2.
DR   AlphaFoldDB; P9WJA4; -.
DR   SMR; P9WJA4; -.
DR   EnsemblBacteria; AAK46276; AAK46276; MT2004.
DR   KEGG; mtc:MT2004; -.
DR   HOGENOM; CLU_133758_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009241; HigB-like.
DR   Pfam; PF05973; Gp49; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Toxin-antitoxin system.
FT   CHAIN           1..125
FT                   /note="Probable endoribonuclease HigB1"
FT                   /id="PRO_0000427864"
SQ   SEQUENCE   125 AA;  14430 MW;  1CB206A94F0A92D5 CRC64;
     MPPPDPAAMG TWKFFRASVD GRPVFKKEFD KLPDQARAAL IVLMQRYLVG DLAAGSIKPI
     RGDILELRWH EANNHFRVLF FRWGQHPVAL TAFYKNQQKT PKTKIETALD RQKIWKRAFG
     DTPPI