HIGB2_MYCTU
ID HIGB2_MYCTU Reviewed; 201 AA.
AC O53468; I6Y858; Q7D7M0;
DT 29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Putative toxin HigB2 {ECO:0000303|PubMed:24662523};
GN Name=higB2 {ECO:0000303|PubMed:24662523};
GN OrderedLocusNames=Rv2022c, RVBD_2022c; ORFNames=LH57_11015, P425_02093;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RG The Broad Institute Genome Sequencing Platform;
RA Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K.,
RA Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T.,
RA Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA Monaco A., King S., Sohrabi A.;
RT "Phylogenetic analysis of Mycobacterial species using whole genome
RT sequences.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INDUCTION IN PERSISTER CELLS.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21673191; DOI=10.1128/mbio.00100-11;
RA Keren I., Minami S., Rubin E., Lewis K.;
RT "Characterization and transcriptome analysis of Mycobacterium tuberculosis
RT persisters.";
RL MBio 2:E00100-E00111(2011).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN [7]
RP DISCUSSION OF POSSIBLE FUNCTION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=24662523; DOI=10.3390/toxins6031002;
RA Sala A., Bordes P., Genevaux P.;
RT "Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.";
RL Toxins 6:1002-1020(2014).
CC -!- FUNCTION: Putative toxic component of a type II toxin-antitoxin (TA)
CC system. Its cognate antitoxin would be HigA2.
CC {ECO:0000305|PubMed:24662523}.
CC -!- INDUCTION: Induced in persister cells in response to D-cycloserine.
CC {ECO:0000269|PubMed:21673191}.
CC -!- SIMILARITY: Belongs to the mycobacterial HigB family. {ECO:0000305}.
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DR EMBL; AL123456; CCP44794.1; -; Genomic_DNA.
DR EMBL; CP003248; AFN49962.1; -; Genomic_DNA.
DR EMBL; CP009480; AIR14772.1; -; Genomic_DNA.
DR EMBL; JLDD01000023; KBJ33166.1; -; Genomic_DNA.
DR RefSeq; NP_216538.1; NC_000962.3.
DR RefSeq; WP_003900449.1; NZ_NVQJ01000046.1.
DR AlphaFoldDB; O53468; -.
DR SMR; O53468; -.
DR STRING; 83332.Rv2022c; -.
DR PaxDb; O53468; -.
DR DNASU; 888129; -.
DR GeneID; 888129; -.
DR KEGG; mtu:Rv2022c; -.
DR KEGG; mtv:RVBD_2022c; -.
DR PATRIC; fig|83332.111.peg.2253; -.
DR TubercuList; Rv2022c; -.
DR eggNOG; COG4683; Bacteria.
DR HOGENOM; CLU_1359168_0_0_11; -.
DR OMA; WYHEKIK; -.
DR PhylomeDB; O53468; -.
DR Proteomes; UP000001584; Chromosome.
DR InterPro; IPR009241; HigB-like.
DR Pfam; PF05973; Gp49; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..201
FT /note="Putative toxin HigB2"
FT /id="PRO_0000432913"
SQ SEQUENCE 201 AA; 22777 MW; 42EC1A055EDDBE1B CRC64;
MNVPWENAHG GALYCLIRGD EFSAWHRLLF QRPGCAESVL ACRHFLDGSP VARCSYPEEY
HPCVISRIAL LCDSVGWTAD VERISAWLNG LDRETYELVF AAIEVLEEEG PALGCPLVDT
VRGSRHKNMK ELRPGSQGRS EVRILFAFDP ARQAIMLAAG NKAGRWTQWY DEKIKAADEM
FAEHLAQFED TKPKRRKRKK G
