ID   HIGB3_MYCTU             Reviewed;         114 AA.
AC   O53332; F2GJP1; I6YFG2; L0TC23;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Putative toxin HigB3 {ECO:0000303|PubMed:24662523};
GN   Name=higB3 {ECO:0000303|PubMed:24662523};
GN   OrderedLocusNames=Rv3182, RVBD_3182; ORFNames=LH57_17365, P425_03314;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RG   The Broad Institute Genome Sequencing Platform;
RA   Galagan J., Kreiswirth B., Dobos K., Fortune S., Fitzgerald M., Young S.K.,
RA   Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA   Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA   Poon T., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A.M., Kreiswirth B., Gomez J., Victor T., Desjardins C., Abeel T.,
RA   Young S., Zeng Q., Gargeya S., Abouelleil A., Alvarado L., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Larimer J., Murphy C., Naylor J., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The genome sequence of Mycobacterium tuberculosis H37Rv.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   EXPRESSION IN M.SMEGMATIS.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
RN   [6]
RP   DISCUSSION OF POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=24662523; DOI=10.3390/toxins6031002;
RA   Sala A., Bordes P., Genevaux P.;
RT   "Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.";
RL   Toxins 6:1002-1020(2014).
CC   -!- FUNCTION: Putative toxic component of a type II toxin-antitoxin (TA)
CC       system. Its cognate antitoxin would be HigA3. Not toxic upon expression
CC       in M.smegmatis. {ECO:0000269|PubMed:20011113,
CC       ECO:0000305|PubMed:24662523}.
CC   -!- SIMILARITY: Belongs to the mycobacterial HigB family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45993.1; -; Genomic_DNA.
DR   EMBL; CP003248; AFN51175.1; -; Genomic_DNA.
DR   EMBL; CP009480; AIR15967.1; -; Genomic_DNA.
DR   EMBL; JLDD01000038; KBJ29228.1; -; Genomic_DNA.
DR   RefSeq; NP_217698.1; NC_000962.3.
DR   RefSeq; WP_003899954.1; NZ_NVQJ01000019.1.
DR   AlphaFoldDB; O53332; -.
DR   SMR; O53332; -.
DR   STRING; 83332.Rv3182; -.
DR   PaxDb; O53332; -.
DR   PRIDE; O53332; -.
DR   DNASU; 888795; -.
DR   GeneID; 888795; -.
DR   KEGG; mtu:Rv3182; -.
DR   KEGG; mtv:RVBD_3182; -.
DR   PATRIC; fig|83332.111.peg.3545; -.
DR   TubercuList; Rv3182; -.
DR   eggNOG; COG4683; Bacteria.
DR   HOGENOM; CLU_107454_1_1_11; -.
DR   OMA; FVFDPWS; -.
DR   PhylomeDB; O53332; -.
DR   Proteomes; UP000001584; Chromosome.
DR   InterPro; IPR009241; HigB-like.
DR   Pfam; PF05973; Gp49; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..114
FT                   /note="Putative toxin HigB3"
FT                   /id="PRO_0000432914"
SQ   SEQUENCE   114 AA;  12692 MW;  119D0463FA24AB59 CRC64;
     MAVILLPQVE RWFFALNRDA MASVTGAIDL LEMEGPTLGR PVVDKVNDST FHNMKELRPA
     GTSIRILFAF DPARQAILLL GGDKAGNWKR WYDNNIPIAD QRSENWLASE HGGG