HIKES_DANRE
ID HIKES_DANRE Reviewed; 197 AA.
AC Q568T4; F1QUB6;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2012, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Protein Hikeshi;
GN Name=hikeshi; ORFNames=zgc:110091;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a specific nuclear import carrier for hsp70 proteins
CC following heat-shock stress: acts by mediating the nucleoporin-
CC dependent translocation of ATP-bound hsp70 proteins into the nucleus.
CC hsp70 proteins import is required to protect cells from heat shock
CC damages (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the OPI10 family. {ECO:0000305}.
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DR EMBL; CU651657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC092729; AAH92729.1; -; mRNA.
DR RefSeq; NP_001017577.1; NM_001017577.1.
DR AlphaFoldDB; Q568T4; -.
DR SMR; Q568T4; -.
DR STRING; 7955.ENSDARP00000059340; -.
DR PaxDb; Q568T4; -.
DR Ensembl; ENSDART00000169685; ENSDARP00000131338; ENSDARG00000104071.
DR GeneID; 550239; -.
DR KEGG; dre:550239; -.
DR CTD; 51501; -.
DR ZFIN; ZDB-GENE-050417-34; hikeshi.
DR eggNOG; KOG4067; Eukaryota.
DR GeneTree; ENSGT00390000004056; -.
DR HOGENOM; CLU_084839_2_0_1; -.
DR InParanoid; Q568T4; -.
DR OMA; RMEQNPN; -.
DR OrthoDB; 1223488at2759; -.
DR PhylomeDB; Q568T4; -.
DR TreeFam; TF313222; -.
DR Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR PRO; PR:Q568T4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 1.
DR Bgee; ENSDARG00000104071; Expressed in muscle tissue and 30 other tissues.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0030544; F:Hsp70 protein binding; ISS:UniProtKB.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR GO; GO:0006606; P:protein import into nucleus; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR InterPro; IPR008493; DUF775.
DR InterPro; IPR031318; OPI10.
DR PANTHER; PTHR12925; PTHR12925; 1.
DR Pfam; PF05603; DUF775; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..197
FT /note="Protein Hikeshi"
FT /id="PRO_0000245266"
FT CONFLICT 162
FT /note="Q -> R (in Ref. 2; AAH92729)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 197 AA; 21444 MW; DD389B69FA07BDEC CRC64;
MFGCLVAGRL VQTDAQQVAS DKFVFNLPDY EHVNHVVVFL LGTVPFPEGL GGAVYLCVPG
GAAGQVWQLL GFITNEKPSA IFRISGLKAG EGSSHPFGMM DAPAAPSMAQ VGVSVEGLHL
LAQQTPVSSS AVSTLDSFTQ FTQKMLDSLF NFTSSFALSQ SQMSPNPSEM FIPASSIRRW
YENFQRRLMQ NPNFWKT
