ID   HIKES_XENLA             Reviewed;         197 AA.
AC   Q6DCU7;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Protein Hikeshi;
GN   Name=hikeshi;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a specific nuclear import carrier for hsp70 proteins
CC       following heat-shock stress: acts by mediating the nucleoporin-
CC       dependent translocation of ATP-bound hsp70 proteins into the nucleus.
CC       hsp70 proteins import is required to protect cells from heat shock
CC       damages (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OPI10 family. {ECO:0000305}.
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DR   EMBL; BC077893; AAH77893.1; -; mRNA.
DR   RefSeq; NP_001087012.1; NM_001093543.1.
DR   AlphaFoldDB; Q6DCU7; -.
DR   SMR; Q6DCU7; -.
DR   MaxQB; Q6DCU7; -.
DR   DNASU; 446847; -.
DR   GeneID; 446847; -.
DR   KEGG; xla:446847; -.
DR   CTD; 446847; -.
DR   Xenbase; XB-GENE-6255100; hikeshi.L.
DR   OMA; RMEQNPN; -.
DR   OrthoDB; 1223488at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 446847; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030544; F:Hsp70 protein binding; ISS:UniProtKB.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0006606; P:protein import into nucleus; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR   InterPro; IPR008493; DUF775.
DR   InterPro; IPR031318; OPI10.
DR   PANTHER; PTHR12925; PTHR12925; 1.
DR   Pfam; PF05603; DUF775; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..197
FT                   /note="Protein Hikeshi"
FT                   /id="PRO_0000245267"
SQ   SEQUENCE   197 AA;  21983 MW;  7B7DCABD60A44287 CRC64;
     MFGCLVAGRL VQTDAQQVAE DKFVFNLPDF ESINHVVVFM LGTVPFPERM GGSVYFSFPD
     QTGMPVWTLL GFITNEKPSA IFKISGLKSG EGSQHPFGTM NLPQTPSVAQ IGISVELLEQ
     MAQQTPVANA AVSTVDSFTQ FTQKMLDNFY NFATSFAVSQ AQMIPNPSEV FIPSNVVLKW
     YENFQRRMAQ NPFFWKT