ID   HIKES_XENTR             Reviewed;         197 AA.
AC   A4IGP0;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Protein Hikeshi;
GN   Name=hikeshi;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a specific nuclear import carrier for hsp70 proteins
CC       following heat-shock stress: acts by mediating the nucleoporin-
CC       dependent translocation of ATP-bound hsp70 proteins into the nucleus.
CC       hsp70 proteins import is required to protect cells from heat shock
CC       damages (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OPI10 family. {ECO:0000305}.
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DR   EMBL; AAMC01059364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01059365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01059366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC135186; AAI35187.1; -; mRNA.
DR   RefSeq; NP_001090793.1; NM_001097324.1.
DR   AlphaFoldDB; A4IGP0; -.
DR   SMR; A4IGP0; -.
DR   STRING; 8364.ENSXETP00000022906; -.
DR   PaxDb; A4IGP0; -.
DR   DNASU; 100037885; -.
DR   GeneID; 100037885; -.
DR   KEGG; xtr:100037885; -.
DR   CTD; 51501; -.
DR   Xenbase; XB-GENE-967059; hikeshi.
DR   eggNOG; KOG4067; Eukaryota.
DR   HOGENOM; CLU_084839_2_0_1; -.
DR   InParanoid; A4IGP0; -.
DR   OMA; MSIIVKW; -.
DR   OrthoDB; 1223488at2759; -.
DR   PhylomeDB; A4IGP0; -.
DR   TreeFam; TF313222; -.
DR   Reactome; R-XTR-3371453; Regulation of HSF1-mediated heat shock response.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000010439; Expressed in skeletal muscle tissue and 13 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030544; F:Hsp70 protein binding; ISS:UniProtKB.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0006606; P:protein import into nucleus; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR   InterPro; IPR008493; DUF775.
DR   InterPro; IPR031318; OPI10.
DR   PANTHER; PTHR12925; PTHR12925; 1.
DR   Pfam; PF05603; DUF775; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..197
FT                   /note="Protein Hikeshi"
FT                   /id="PRO_0000417992"
SQ   SEQUENCE   197 AA;  22003 MW;  B24E0CFFBB737D37 CRC64;
     MFGCLVAGRL VQTDAQQVAE DKFVFNLPDY ESINHVVVFM LGTVPFPERM GGSVYFSYPD
     QSGMPVWTLL GFITNEKPSA IFKISGLKSG EGSQHPFGTM NIPQTPSVAQ IGISVELLEQ
     MAQQTPVANA AVSTIDSFTQ FTQKMLDNFY NFATSFAVSQ AQMTPNPSEV FIPSNVVLKW
     YENFQRRMAQ NPFFWKT