ID   HILA_SALPA              Reviewed;         553 AA.
AC   Q5PEB1;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Transcriptional regulator HilA;
DE            Short=Protein IagA;
GN   Name=hilA; Synonyms=iagA; OrderedLocusNames=SPA2734;
OS   Salmonella paratyphi A (strain ATCC 9150 / SARB42).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=295319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9150 / SARB42;
RX   PubMed=15531882; DOI=10.1038/ng1470;
RA   McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S.,
RA   Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R.,
RA   Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F.,
RA   Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W.,
RA   Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M.,
RA   Warren W., Florea L., Spieth J., Wilson R.K.;
RT   "Comparison of genome degradation in Paratyphi A and Typhi, human-
RT   restricted serovars of Salmonella enterica that cause typhoid.";
RL   Nat. Genet. 36:1268-1274(2004).
CC   -!- FUNCTION: The main transcriptional regulator of the Salmonella
CC       pathogenicity island 1 (SPI1) gene expression. Activates the expression
CC       of invasion genes by a direct action at their promoters and also
CC       indirectly by increasing the level of invF. Also binds upstream of prgH
CC       and directly activates the expression of prgHIJK operon (By
CC       similarity). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in response to both environmental conditions and
CC       genetic regulatory factors. Transcription is subject to complex control
CC       and is stimulated by the SPI1-encoded HilC and HilD (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; CP000026; AAV78591.1; -; Genomic_DNA.
DR   RefSeq; WP_001120088.1; NC_006511.1.
DR   AlphaFoldDB; Q5PEB1; -.
DR   SMR; Q5PEB1; -.
DR   EnsemblBacteria; AAV78591; AAV78591; SPA2734.
DR   KEGG; spt:SPA2734; -.
DR   HOGENOM; CLU_034088_0_0_6; -.
DR   OMA; FASAYGM; -.
DR   Proteomes; UP000008185; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Phosphoprotein; TPR repeat; Transcription;
KW   Transcription regulation; Two-component regulatory system; Virulence.
FT   CHAIN           1..553
FT                   /note="Transcriptional regulator HilA"
FT                   /id="PRO_0000081106"
FT   REPEAT          372..405
FT                   /note="TPR"
FT   DNA_BIND        11..107
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         62
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   553 AA;  63071 MW;  B854EF8D89CE0443 CRC64;
     MPHFNPVPVS NKKFVFDDFI LNMDGSLLRS EKKVNIPPKE YAVLVILLEA AGEIVSKNTL
     LDQVWGDAEV NEESLTRCIY ALRRILSEDK EHRYIETLYG QGYRFNRPVV VVSPPAPQPT
     THTLAILPFQ MQDQVQSESL HYSIVKGLSQ YAPFGLSVLP VTITKNCRSV KDILELMDQL
     RPDYYISGQM IPDGNDNIVQ IEIVRVKGYH LLHQESIKLI EHQPASLLQN KIANLLLRCI
     PGLRWDTKQI SELNSIDSTM VYLRGKHELN QYTPYSLQQA LKLLTQCVNM SPNSIAPYCA
     LAECYLSMTQ MGIFDKQNAM IKAKEHAIKA TELDHNNPQA LGLLGLINTI HSEYIVGSLL
     FKQANLLSPI SADIKYYYGW NLFMAGQLEE ALQTINECLK LDPTRAAAGI TKLWITYYHT
     GIDDAIRLGD ELRSQHLQDN PILLSMQVMF LSLKGKHELA RKLTKEISTQ EITGLIAVNL
     LYAEYCQNSE RALPTIREFL ESEQRIDNNP GLLPLVLVAH GEAIAEKMWN KFKNEDNIWF
     KRWKQDPRLI KLR