ID   HILA_SALTI              Reviewed;         553 AA.
AC   P43016;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2001, sequence version 2.
DT   25-MAY-2022, entry version 144.
DE   RecName: Full=Transcriptional regulator HilA;
DE            Short=Protein IagA;
GN   Name=hilA; Synonyms=iagA; OrderedLocusNames=STY2999, t2778;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=7754225; DOI=10.1016/0923-2508(96)80267-1;
RA   Miras I., Hermant D., Arricau N., Popoff M.Y.;
RT   "Nucleotide sequence of iagA and iagB genes involved in invasion of HeLa
RT   cells by Salmonella enterica subsp. enterica ser. Typhi.";
RL   Res. Microbiol. 146:17-20(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: The main transcriptional regulator of the Salmonella
CC       pathogenicity island 1 (SPI1) gene expression. Activates the expression
CC       of invasion genes by a direct action at their promoters and also
CC       indirectly by increasing the level of invF. Also binds upstream of prgH
CC       and directly activates the expression of prgHIJK operon (By
CC       similarity). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in response to both environmental conditions and
CC       genetic regulatory factors. Transcription is subject to complex control
CC       and is stimulated by the SPI1-encoded HilC and HilD (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; X80892; CAA56853.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD05983.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70339.1; -; Genomic_DNA.
DR   RefSeq; NP_457270.1; NC_003198.1.
DR   RefSeq; WP_001120092.1; NZ_WSUR01000005.1.
DR   AlphaFoldDB; P43016; -.
DR   SMR; P43016; -.
DR   STRING; 220341.16503954; -.
DR   EnsemblBacteria; AAO70339; AAO70339; t2778.
DR   KEGG; stt:t2778; -.
DR   KEGG; sty:STY2999; -.
DR   PATRIC; fig|220341.7.peg.3053; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG3710; Bacteria.
DR   HOGENOM; CLU_034088_0_0_6; -.
DR   OMA; FASAYGM; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Phosphoprotein; TPR repeat; Transcription;
KW   Transcription regulation; Two-component regulatory system; Virulence.
FT   CHAIN           1..553
FT                   /note="Transcriptional regulator HilA"
FT                   /id="PRO_0000081107"
FT   REPEAT          372..405
FT                   /note="TPR"
FT   DNA_BIND        11..107
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         62
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        28
FT                   /note="L -> V (in Ref. 1; CAA56853)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   553 AA;  63040 MW;  B124EF8D8C08A443 CRC64;
     MPHFNPVPVS NKKFVFDDFI LNMDGSLLRS EKKVNIPPKE YAVLVILLEA AGKIVSKNTL
     LDQVWGDAEV NEESLTRCIY ALRRILSEDK EHRYIETLYG QGYRFNRPVV VVSPPAPQPT
     THTLAILPFQ MQDQVQSESL HYSIVKGLSQ YAPFGLSVLP VTITKNCRSV KDILELMDQL
     RPDYYISGQM IPDGNDNIVQ IEIVRVKGYH LLHQESIKLI EHQPASLLQN KIANLLLRCI
     PGLRWDTKQI SELNSIDSTM VYLRGKHELN QYTPYSLQQA LKLLTQCVNM SPNSIAPYCA
     LAECYLSMAQ MGIFDKQNAM IKAKEHAIKA TELDHNNPQA LGLLGLINTI HSEYIVGSLL
     FKQANLLSPI SADIKYYYGW NLFMAGQLEE ALQTINECLK LDPTRAAAGI TKLWITYYHT
     GIDDAIRLGD ELRSQHLQDN PILLSMQVMF LSLKGKHELA RKLTKEISTQ EITGLIAVNL
     LYAEYCQNSE RALPTIREFL ESEQRIDNNP GLLPLVLVAH GEAIAEKMWN KFKNEDNIWF
     KRWKQDPRLI KLR