ID   HILS1_HUMAN             Reviewed;         231 AA.
AC   P60008;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2003, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Putative spermatid-specific linker histone H1-like protein {ECO:0000305};
DE   AltName: Full=H1.9 linker histone pseudogene {ECO:0000312|HGNC:HGNC:30616};
GN   Name=H1-9P {ECO:0000312|HGNC:HGNC:30616};
GN   Synonyms=H1-9 {ECO:0000312|HGNC:HGNC:30616},
GN   HILS1 {ECO:0000312|HGNC:HGNC:30616};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], CAUTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=12920187; DOI=10.1073/pnas.1837812100;
RA   Yan W., Ma L., Burns K.H., Matzuk M.M.;
RT   "HILS1 is a spermatid-specific linker histone H1-like protein implicated in
RT   chromatin remodeling during mammalian spermiogenesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10546-10551(2003).
CC   -!- FUNCTION: DNA-binding protein that may be implicated in chromatin
CC       remodeling and/or transcriptional regulation during spermiogenesis, the
CC       process of spermatid maturation into spermatozoa.
CC       {ECO:0000250|UniProtKB:Q9QYL0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}.
CC       Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in the testis.
CC       {ECO:0000269|PubMed:12920187}.
CC   -!- SIMILARITY: Belongs to the histone H1/H5 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00837}.
CC   -!- CAUTION: Could be the product of a pseudogene. However, mouse (AC
CC       Q9QYL0) and rat (AC D3ZZW6) orthologs encode functional proteins.
CC       {ECO:0000305|PubMed:12920187}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY286318; AAQ23050.1; -; mRNA.
DR   AlphaFoldDB; P60008; -.
DR   SMR; P60008; -.
DR   IntAct; P60008; 1.
DR   iPTMnet; P60008; -.
DR   PhosphoSitePlus; P60008; -.
DR   BioMuta; HGNC:30616; -.
DR   DMDM; 38372285; -.
DR   MassIVE; P60008; -.
DR   PRIDE; P60008; -.
DR   GeneCards; H1-9P; -.
DR   HGNC; HGNC:30616; H1-9P.
DR   MIM; 608101; gene.
DR   neXtProt; NX_P60008; -.
DR   InParanoid; P60008; -.
DR   PhylomeDB; P60008; -.
DR   PathwayCommons; P60008; -.
DR   Pharos; P60008; Tbio.
DR   PRO; PR:P60008; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; P60008; protein.
DR   GO; GO:0001673; C:male germ cell nucleus; IDA:UniProtKB.
DR   GO; GO:0000786; C:nucleosome; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IDA:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IDA:UniProtKB.
DR   GO; GO:0031492; F:nucleosomal DNA binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; NAS:UniProtKB.
DR   GO; GO:0030261; P:chromosome condensation; IDA:UniProtKB.
DR   GO; GO:0007281; P:germ cell development; IDA:UniProtKB.
DR   GO; GO:0031507; P:heterochromatin assembly; IDA:UniProtKB.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IDA:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005818; Histone_H1/H5_H15.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00538; Linker_histone; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS51504; H15; 1.
PE   5: Uncertain;
KW   Chromatin regulator; Chromosome; Developmental protein; Differentiation;
KW   DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Spermatogenesis;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..231
FT                   /note="Putative spermatid-specific linker histone H1-like
FT                   protein"
FT                   /id="PRO_0000196014"
FT   DOMAIN          113..177
FT                   /note="H15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   REGION          177..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..195
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         135
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:D3ZZW6"
SQ   SEQUENCE   231 AA;  25632 MW;  DF3612D213CB406F CRC64;
     MLHASTIWHL RSTPPRRKQW GHCDPHRILV ASEVTTEITS PTPAPRAQVC GGQPWVTVLD
     PLSGHTGREA ERHFATVSIS AVELKYCHGW RPAGQRVPSK TATGQRTCAK PCQKPSTSKV
     ILRAVADKGT CKYVSLATLK KAVSTTGYDM ARNAYHFKRV LKGLVDKGSA GSFTLGKKQA
     SKSKLKVKRQ RQQRWRSGQR PFGQHRSLLG SKQGHKRLIK GVRRVAKCHC N