ID   HIM1_YEAST              Reviewed;         414 AA.
AC   Q06674; D6VSU8;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Protein HIM1;
DE   AltName: Full=High induction of mutagenesis protein 1;
GN   Name=HIM1; OrderedLocusNames=YDR317W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION.
RX   PubMed=15885712; DOI=10.1016/j.mrfmmm.2005.03.003;
RA   Kelberg E.P., Kovaltsova S.V., Alekseev S.Y., Fedorova I.V., Gracheva L.M.,
RA   Evstukhina T.A., Korolev V.G.;
RT   "HIM1, a new yeast Saccharomyces cerevisiae gene playing a role in control
RT   of spontaneous and induced mutagenesis.";
RL   Mutat. Res. 578:64-78(2005).
CC   -!- FUNCTION: May participate in the control of processing of mutational
CC       intermediates appearing during error-prone bypass of DNA damage.
CC       {ECO:0000269|PubMed:15885712}.
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DR   EMBL; U32517; AAB64753.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA12158.1; -; Genomic_DNA.
DR   PIR; S59783; S59783.
DR   RefSeq; NP_010603.3; NM_001180625.3.
DR   AlphaFoldDB; Q06674; -.
DR   BioGRID; 32373; 45.
DR   DIP; DIP-4660N; -.
DR   STRING; 4932.YDR317W; -.
DR   PaxDb; Q06674; -.
DR   PRIDE; Q06674; -.
DR   EnsemblFungi; YDR317W_mRNA; YDR317W; YDR317W.
DR   GeneID; 851915; -.
DR   KEGG; sce:YDR317W; -.
DR   SGD; S000002725; HIM1.
DR   VEuPathDB; FungiDB:YDR317W; -.
DR   eggNOG; ENOG502RZQF; Eukaryota.
DR   HOGENOM; CLU_036495_0_0_1; -.
DR   InParanoid; Q06674; -.
DR   OMA; TIDYINM; -.
DR   BioCyc; YEAST:G3O-29875-MON; -.
DR   PRO; PR:Q06674; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; Q06674; protein.
DR   GO; GO:0006281; P:DNA repair; IGI:SGD.
DR   InterPro; IPR014843; Him1/Fmp52.
DR   Pfam; PF08732; HIM1; 1.
PE   4: Predicted;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..414
FT                   /note="Protein HIM1"
FT                   /id="PRO_0000233013"
SQ   SEQUENCE   414 AA;  47337 MW;  E2DC5EFC1FF384C0 CRC64;
     MSYSVNTFTD YVLLFGSSSL VGKGILENLL DINLYIKNVS DLQGKLDSLS EIKGNVVLNK
     HVFCVNRRCI NEEKSFMKTI DYINMRSVTW QGGRYYLRSR KEKDTEKVPS SPNTFCYDNF
     EEGFIKNTPE ERGKDGYSFV YNQKQFSYTL HYACGKEKGI EIICNFTVTQ LIIPRSETWP
     KLLPRIFSGT QKLEKFDIDN KNYVPGRSLP SLCDISTMVC SLGSTSARVR RTQVPSSFAD
     YYLPFNLAQE FTNTTNKRLV VTTAFNNDFL SKTFEYFRIK AKLENDLDEA LPNKLKELVI
     LRPGPMCGQH GNPINVELGK ENSTFLEKIF YYPHYLLVYK KKYISEARRI GLRTKLSEII
     ASSIYRMPGS ALLGYAVPVS KVSYVASLMA IERKSKEAGP KLEVISSYQI DMIV