ID   HIMD_ASPJA              Reviewed;         598 AA.
AC   A0A2Z5U1Z1;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2018, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Transcription factor himD {ECO:0000303|PubMed:29314577};
DE   AltName: Full=Himeic acid A biosynthesis cluster protein D {ECO:0000303|PubMed:29314577};
GN   Name=himD {ECO:0000303|PubMed:29314577};
OS   Aspergillus japonicus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=34381;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=MF275;
RX   PubMed=29314577; DOI=10.1002/cbic.201700584;
RA   Hashimoto M., Kato H., Katsuki A., Tsukamoto S., Fujii I.;
RT   "Identification of the biosynthetic gene cluster for himeic acid A: a
RT   ubiquitin-activating enzyme (E1) inhibitor in Aspergillus japonicus
RT   MF275.";
RL   ChemBioChem 19:535-539(2018).
CC   -!- FUNCTION: Transcription factor that, with himB, probably co-regulates
CC       the him gene cluster that mediates the biosynthesis of himeic acid A, a
CC       ubiquitin-activating enzyme (E1) inhibitor.
CC       {ECO:0000305|PubMed:29314577}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; LC331673; BBA91556.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z5U1Z1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..598
FT                   /note="Transcription factor himD"
FT                   /id="PRO_0000445948"
FT   DNA_BIND        18..47
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          87..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   598 AA;  68003 MW;  69DA3295B04C100D CRC64;
     MSDRTRTTRY ANGSLRTCQN CARAKIRCIR SVPTGSCDRC ERLRKTCQFQ PGRRANAGPS
     LSESKDRRID ALEAKLDRLL AQSTSATVSE ASIDDKSPTT TPTTPRPPPD VIDSGLLTLE
     AASLLLQDYQ RTLMPYCPFV MVPSPATAAT LRRDKPFLFL AILTAALYDN MPLQRTLELE
     VKRTIGRCMI FDGPVSFDML QGLLVHLAWC QYHSRPRRFS QYLHLAISII TDLQLDRAPE
     DRFWRTRVDF NGELDREISW GREERRAVVG FFWFSSSISQ ILQKRSSFSF IPYLETSCEL
     LASTAEYDSD QHLLQLIQLQ RLSERIIVAS GQHTSEPHDA DALEQCYRDR RSELDLYLAQ
     LPFPLTDSHL LMMQYHTVEL YLCQVTLFDH KPSAQRPRHD SPFPIEALRM GLTAARTLLD
     FYISLPLRRE VAFNNAGWVQ LGFVVTLACK LAVAAADPHI HPHMADLTRA LDLSTMLSRC
     ILRIQALVTS QMDARGDRDV FYHYEKRLKR AQWWFESRSL SRSQQQRNEP LPVAGAGEAS
     SPRNARIAEI PAEEEFQVGY AAVSGDGFDF QWPGLFPDPT FDDMFGDWMA QGSSGFDD