ID   HIME_ASPJA              Reviewed;         321 AA.
AC   A0A2Z5TTA9;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2018, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Efflux pump himE {ECO:0000303|PubMed:29314577};
DE   AltName: Full=Himeic acid A biosynthesis cluster protein E {ECO:0000303|PubMed:29314577};
GN   Name=himE {ECO:0000303|PubMed:29314577};
OS   Aspergillus japonicus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=34381;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=MF275;
RX   PubMed=29314577; DOI=10.1002/cbic.201700584;
RA   Hashimoto M., Kato H., Katsuki A., Tsukamoto S., Fujii I.;
RT   "Identification of the biosynthetic gene cluster for himeic acid A: a
RT   ubiquitin-activating enzyme (E1) inhibitor in Aspergillus japonicus
RT   MF275.";
RL   ChemBioChem 19:535-539(2018).
CC   -!- FUNCTION: Efflux pump that is probably involved in the efflux of himeic
CC       acid A, a ubiquitin-activating enzyme (E1) inhibitor.
CC       {ECO:0000305|PubMed:29314577}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the lipid-translocating exporter (LTE) (TC
CC       9.A.26.1) family. {ECO:0000305}.
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DR   EMBL; LC331673; BBA91555.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2Z5TTA9; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007568; RTA1.
DR   PANTHER; PTHR31465; PTHR31465; 1.
DR   Pfam; PF04479; RTA1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..321
FT                   /note="Efflux pump himE"
FT                   /id="PRO_0000445953"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   321 AA;  35235 MW;  E8E12B3022F72694 CRC64;
     MSNSTDPSDY CTFEICPITE AYVYYVPSLA GNAFYLALFA VLLAAQLVLA VRYRTWGYLA
     GLSGGLILEI IGYIGRIQLH SNPFRFGPYL EYLICLTIGP AILSASIYIC LGRIVIVYGE
     GISRLRPKTY TMVFVACDLV SLVLQAAGGA ITSVADADQY DLAQDGINIM IAGLASQVAS
     LALFMALCLD YAWRVYKSPH NLSPETRMRD LRHSLRWKAF LAGLALATVA IFMRSVFRVA
     ELKGGFHSSL ANDQVLFMTL EGAMIAIAVI ALTVLHPGLC FDGLWDQTKW SFRRSRDSEM
     QLIEVSAGHE AKAQRADLGM S