ID   HINT_CAEEL              Reviewed;         130 AA.
AC   P53795;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Histidine triad nucleotide-binding protein 1;
GN   Name=hint-1; ORFNames=F21C3.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; Z71261; CAA95802.1; -; Genomic_DNA.
DR   PIR; T21189; T21189.
DR   RefSeq; NP_492056.1; NM_059655.4.
DR   AlphaFoldDB; P53795; -.
DR   SMR; P53795; -.
DR   BioGRID; 49547; 7.
DR   STRING; 6239.F21C3.3; -.
DR   EPD; P53795; -.
DR   PaxDb; P53795; -.
DR   PeptideAtlas; P53795; -.
DR   EnsemblMetazoa; F21C3.3.1; F21C3.3.1; WBGene00009002.
DR   EnsemblMetazoa; F21C3.3.2; F21C3.3.2; WBGene00009002.
DR   GeneID; 184760; -.
DR   KEGG; cel:CELE_F21C3.3; -.
DR   CTD; 184760; -.
DR   WormBase; F21C3.3; CE05678; WBGene00009002; hint-1.
DR   eggNOG; KOG3275; Eukaryota.
DR   GeneTree; ENSGT00940000154451; -.
DR   HOGENOM; CLU_056776_8_1_1; -.
DR   InParanoid; P53795; -.
DR   OMA; IAFMDIM; -.
DR   OrthoDB; 1190598at2759; -.
DR   PhylomeDB; P53795; -.
DR   PRO; PR:P53795; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00009002; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR   GO; GO:0009154; P:purine ribonucleotide catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.428.10; -; 1.
DR   InterPro; IPR019808; Histidine_triad_CS.
DR   InterPro; IPR001310; Histidine_triad_HIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR23089; PTHR23089; 1.
DR   Pfam; PF01230; HIT; 1.
DR   PRINTS; PR00332; HISTRIAD.
DR   SUPFAM; SSF54197; SSF54197; 1.
DR   PROSITE; PS00892; HIT_1; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..130
FT                   /note="Histidine triad nucleotide-binding protein 1"
FT                   /id="PRO_0000109806"
FT   DOMAIN          22..130
FT                   /note="HIT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00464"
FT   MOTIF           114..118
FT                   /note="Histidine triad motif"
SQ   SEQUENCE   130 AA;  14243 MW;  94DE169C0529AC84 CRC64;
     MSEVDKAHLA AINKDVQAND TLFGKIIRKE IPAKIIFEDD EALAFHDVSP QAPIHFLVIP
     KRRIDMLENA VDSDAALIGK LMVTASKVAK QLGMANGYRV VVNNGKDGAQ SVFHLHLHVL
     GGRQLQWPPG