HIP13_ARATH
ID HIP13_ARATH Reviewed; 139 AA.
AC Q9LTE2; Q8LDN0;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 13 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP13 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Flags: Precursor;
GN Name=HIPP13 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN OrderedLocusNames=At5g52750 {ECO:0000312|Araport:AT5G52750};
GN ORFNames=F6N7.24 {ECO:0000312|EMBL:BAA98093.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAA98093.1};
RN [1] {ECO:0000312|EMBL:AAN60294.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Stracke R., Palme K.;
RT "Signal peptide selection derived cDNAs from Arabidopsis thaliana leaves
RT and guard cells.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Quinitio C., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [9]
RP GENE FAMILY, NOMENCLATURE, AND INDUCTION BY CADMIUM.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- FUNCTION: Probable heavy-metal-binding protein.
CC {ECO:0000250|UniProtKB:Q9LZF1}.
CC -!- INDUCTION: Up-regulated by cadmium. {ECO:0000303|PubMed:23368984}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC -!- CAUTION: Contains an apparent HMA-like domain but lacks the core
CC conserved Cys-X-X-Cys motif. {ECO:0000305|PubMed:21072340}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM63117.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF083736; AAN60294.1; -; mRNA.
DR EMBL; AB025606; BAA98093.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96256.1; -; Genomic_DNA.
DR EMBL; AK117134; BAC41812.1; -; mRNA.
DR EMBL; BT003668; AAO39896.1; -; mRNA.
DR EMBL; BT025501; ABF58919.1; -; mRNA.
DR EMBL; AY085905; AAM63117.1; ALT_INIT; mRNA.
DR RefSeq; NP_200087.1; NM_124653.4.
DR AlphaFoldDB; Q9LTE2; -.
DR SMR; Q9LTE2; -.
DR IntAct; Q9LTE2; 1.
DR STRING; 3702.AT5G52750.1; -.
DR PaxDb; Q9LTE2; -.
DR PRIDE; Q9LTE2; -.
DR ProteomicsDB; 230349; -.
DR EnsemblPlants; AT5G52750.1; AT5G52750.1; AT5G52750.
DR GeneID; 835352; -.
DR Gramene; AT5G52750.1; AT5G52750.1; AT5G52750.
DR KEGG; ath:AT5G52750; -.
DR Araport; AT5G52750; -.
DR TAIR; locus:2149594; AT5G52750.
DR HOGENOM; CLU_092610_3_3_1; -.
DR InParanoid; Q9LTE2; -.
DR OMA; MPPMKAV; -.
DR OrthoDB; 1573507at2759; -.
DR PhylomeDB; Q9LTE2; -.
DR PRO; PR:Q9LTE2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LTE2; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR PROSITE; PS50846; HMA_2; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome.
FT CHAIN 1..136
FT /note="Heavy metal-associated isoprenylated plant protein
FT 13"
FT /id="PRO_0000437815"
FT PROPEP 137..139
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437816"
FT DOMAIN 3..70
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REGION 70..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 136
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 136
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 139 AA; 15483 MW; F23D0A026D86EA97 CRC64;
MPPMKAVLQL SIHEERIRKK AFVTVSRCPG VTSITMDDKT GKMTVVGEVD VPVIVMKLRK
LCNTELVSVE VVKPPEKKPE PEKPAPPKPA PAPAKPAEIV AWPVQMNNPY QYNPAYANSY
YQPYGNSRFV TDESNCVIM
