HIP14_ARATH
ID HIP14_ARATH Reviewed; 126 AA.
AC Q9LTE1;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 14 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP14 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Flags: Precursor;
GN Name=HIPP14 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN OrderedLocusNames=At5g52760 {ECO:0000312|Araport:AT5G52760};
GN ORFNames=F6N7.25 {ECO:0000312|EMBL:BAA98094.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAA98094.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [6]
RP GENE FAMILY, NOMENCLATURE, AND INDUCTION BY CADMIUM.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- FUNCTION: Probable heavy-metal-binding protein.
CC {ECO:0000250|UniProtKB:Q9LZF1}.
CC -!- INDUCTION: Up-regulated by cadmium. {ECO:0000303|PubMed:23368984}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC -!- CAUTION: Contains an apparent HMA-like domain but lacks the core
CC conserved Cys-X-X-Cys motif. {ECO:0000305|PubMed:21072340}.
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DR EMBL; AB025606; BAA98094.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96257.1; -; Genomic_DNA.
DR EMBL; BT006168; AAP04152.1; -; mRNA.
DR EMBL; BT008537; AAP40364.1; -; mRNA.
DR EMBL; AK229625; BAF01470.1; -; mRNA.
DR RefSeq; NP_200088.1; NM_124654.5.
DR AlphaFoldDB; Q9LTE1; -.
DR SMR; Q9LTE1; -.
DR STRING; 3702.AT5G52760.1; -.
DR PaxDb; Q9LTE1; -.
DR PRIDE; Q9LTE1; -.
DR ProteomicsDB; 230280; -.
DR EnsemblPlants; AT5G52760.1; AT5G52760.1; AT5G52760.
DR GeneID; 835353; -.
DR Gramene; AT5G52760.1; AT5G52760.1; AT5G52760.
DR KEGG; ath:AT5G52760; -.
DR Araport; AT5G52760; -.
DR TAIR; locus:2149614; AT5G52760.
DR HOGENOM; CLU_092610_3_3_1; -.
DR OMA; HAYANSY; -.
DR OrthoDB; 1573507at2759; -.
DR PhylomeDB; Q9LTE1; -.
DR PRO; PR:Q9LTE1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LTE1; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR PROSITE; PS50846; HMA_2; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome.
FT CHAIN 1..123
FT /note="Heavy metal-associated isoprenylated plant protein
FT 14"
FT /id="PRO_0000437817"
FT PROPEP 124..126
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437818"
FT DOMAIN 3..69
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT MOD_RES 123
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 123
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 126 AA; 14078 MW; EE660BA5A120B5EC CRC64;
MTAKNAVLQL SIHEERTRKK ALVTVSRFSG VTSITMDKSG KMTIVGEVDV PAVVMKLRKL
CNTEIVSVDD VKPPVKKPEP EKPAESIAYP VPMNYAYQFN PAYANSYYHQ PYGNCRVVDE
PNCVIM
