HIP15_ARATH
ID HIP15_ARATH Reviewed; 113 AA.
AC Q9CAK6;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 15 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP15 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Flags: Precursor;
GN Name=HIPP15 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN OrderedLocusNames=At1g63950 {ECO:0000312|Araport:AT1G63950};
GN ORFNames=T12P18.3 {ECO:0000312|EMBL:AAG52453.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=16299181; DOI=10.1104/pp.105.067314;
RA Yu H.-J., Hogan P., Sundaresan V.;
RT "Analysis of the female gametophyte transcriptome of Arabidopsis by
RT comparative expression profiling.";
RL Plant Physiol. 139:1853-1869(2005).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- FUNCTION: Probable heavy-metal-binding protein.
CC {ECO:0000250|UniProtKB:Q9LZF1}.
CC -!- TISSUE SPECIFICITY: Expressed in embryo sacs.
CC {ECO:0000269|PubMed:16299181}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC -!- CAUTION: The HMA domain lacks the core conserved Cys-X-X-Cys motif.
CC {ECO:0000305|PubMed:21072340}.
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DR EMBL; AC010852; AAG52453.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34172.1; -; Genomic_DNA.
DR EMBL; DQ056506; AAY78663.1; -; mRNA.
DR PIR; F96664; F96664.
DR RefSeq; NP_176578.1; NM_105068.2.
DR AlphaFoldDB; Q9CAK6; -.
DR SMR; Q9CAK6; -.
DR STRING; 3702.AT1G63950.1; -.
DR PaxDb; Q9CAK6; -.
DR PRIDE; Q9CAK6; -.
DR ProteomicsDB; 230341; -.
DR EnsemblPlants; AT1G63950.1; AT1G63950.1; AT1G63950.
DR GeneID; 842698; -.
DR Gramene; AT1G63950.1; AT1G63950.1; AT1G63950.
DR KEGG; ath:AT1G63950; -.
DR Araport; AT1G63950; -.
DR TAIR; locus:2195493; AT1G63950.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_2136930_0_0_1; -.
DR PhylomeDB; Q9CAK6; -.
DR PRO; PR:Q9CAK6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9CAK6; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; SSF55008; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Lipoprotein; Metal-binding; Methylation; Prenylation;
KW Reference proteome.
FT CHAIN 1..110
FT /note="Heavy metal-associated isoprenylated plant protein
FT 15"
FT /id="PRO_0000437819"
FT PROPEP 111..113
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437820"
FT DOMAIN 1..65
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT COILED 69..89
FT /evidence="ECO:0000255"
FT MOD_RES 110
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 110
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 113 AA; 13153 MW; 4B9B0F84BB6170F8 CRC64;
MIVWMGVYDQ RSKGKITKSI SDLPGIHSSY MDLKEGTLVV MGDVDPVELV RNLRKKWGKA
KLTLYVPYDA LKEAKIAEAK QKREEIEREA LYRYNREIRD IFNDKEEQGC VIC
