HIP16_ARATH
ID HIP16_ARATH Reviewed; 157 AA.
AC Q9SSF0; Q9ZRE6;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 16 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP16 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE AltName: Full=Farnesylated protein 4 {ECO:0000303|PubMed:8837031};
DE Short=AtFP4 {ECO:0000303|PubMed:8837031};
DE Flags: Precursor;
GN Name=HIPP16 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN Synonyms=FP4 {ECO:0000303|PubMed:8837031};
GN OrderedLocusNames=At3g07600 {ECO:0000312|Araport:AT3G07600};
GN ORFNames=MLP3.5 {ECO:0000312|EMBL:AAF13078.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8837031; DOI=10.1007/bf02900363;
RA Crowell D.N., Biermann B.J., Randall S.K.;
RT "Identification of cDNAs encoding isoprenylated proteins.";
RL Mol. Biotechnol. 5:253-258(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- FUNCTION: Probable heavy-metal-binding protein.
CC {ECO:0000250|UniProtKB:Q9LZF1}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC -!- CAUTION: Contains an apparent HMA-like domain but lacks the core
CC conserved Cys-X-X-Cys motif. {ECO:0000305|PubMed:21072340}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD09508.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U64907; AAD09508.1; ALT_INIT; mRNA.
DR EMBL; AC009176; AAF13078.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74572.1; -; Genomic_DNA.
DR RefSeq; NP_187417.1; NM_111639.1.
DR AlphaFoldDB; Q9SSF0; -.
DR SMR; Q9SSF0; -.
DR STRING; 3702.AT3G07600.1; -.
DR PaxDb; Q9SSF0; -.
DR PRIDE; Q9SSF0; -.
DR ProteomicsDB; 230326; -.
DR EnsemblPlants; AT3G07600.1; AT3G07600.1; AT3G07600.
DR GeneID; 819951; -.
DR Gramene; AT3G07600.1; AT3G07600.1; AT3G07600.
DR KEGG; ath:AT3G07600; -.
DR Araport; AT3G07600; -.
DR TAIR; locus:2091112; AT3G07600.
DR eggNOG; KOG0017; Eukaryota.
DR HOGENOM; CLU_1680331_0_0_1; -.
DR InParanoid; Q9SSF0; -.
DR OMA; RDNCSIM; -.
DR OrthoDB; 1598510at2759; -.
DR PRO; PR:Q9SSF0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SSF0; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR044296; HIPP16/46/47.
DR PANTHER; PTHR46371; PTHR46371; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome.
FT CHAIN 1..154
FT /note="Heavy metal-associated isoprenylated plant protein
FT 16"
FT /id="PRO_0000437821"
FT PROPEP 155..157
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437822"
FT DOMAIN 2..71
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REGION 73..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 154
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 154
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 157 AA; 17936 MW; CBDFB550B61BF945 CRC64;
MKQKILIRIA MTDDTTRAKA MKTAVQFKGV NAVEIKGDHR NQIEVTGVEV DMIALINTLR
KKVAFAELVS VAKVEPPKDG DKKPEEEKKP EEKKPEEKKP EEKKPEPCCQ PWQKPEPCYQ
PWPHDGYGVP SSYPYPCDPY NQIGEPVYNQ DPNCRIM
