HIP18_ARATH
ID HIP18_ARATH Reviewed; 195 AA.
AC Q9T0K9;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 18 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP18 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE AltName: Full=Protein maternal effect embryo arrest 56 {ECO:0000303|PubMed:15634699};
DE Flags: Precursor;
GN Name=HIPP18 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN Synonyms=MEE56 {ECO:0000303|PubMed:15634699};
GN OrderedLocusNames=At4g13380 {ECO:0000312|Araport:AT4G13380};
GN ORFNames=T9E8.120 {ECO:0000312|EMBL:CAB40773.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, AND NOMENCLATURE.
RX PubMed=15634699; DOI=10.1242/dev.01595;
RA Pagnussat G.C., Yu H.-J., Ngo Q.A., Rajani S., Mayalagu S., Johnson C.S.,
RA Capron A., Xie L.-F., Ye D., Sundaresan V.;
RT "Genetic and molecular identification of genes required for female
RT gametophyte development and function in Arabidopsis.";
RL Development 132:603-614(2005).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=18923020; DOI=10.1104/pp.108.128108;
RA Day R.C., Herridge R.P., Ambrose B.A., Macknight R.C.;
RT "Transcriptome analysis of proliferating Arabidopsis endosperm reveals
RT biological implications for the control of syncytial division, cytokinin
RT signaling, and gene expression regulation.";
RL Plant Physiol. 148:1964-1984(2008).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- FUNCTION: Probable heavy-metal-binding protein (By similarity).
CC Required for female gametophyte development and function
CC (PubMed:15634699). {ECO:0000250|UniProtKB:Q9LZF1,
CC ECO:0000269|PubMed:15634699}.
CC -!- DEVELOPMENTAL STAGE: Expressed very early during embryo and endosperm
CC formation and during the proliferative stage of endosperm development
CC at 4 days after pollination. {ECO:0000269|PubMed:18923020}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC -!- CAUTION: The HMA domain lacks the core conserved Cys-X-X-Cys motif.
CC {ECO:0000305|PubMed:21072340}.
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DR EMBL; AL049608; CAB40773.1; -; Genomic_DNA.
DR EMBL; AL161536; CAB78380.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE83272.1; -; Genomic_DNA.
DR PIR; T06295; T06295.
DR RefSeq; NP_193074.1; NM_117412.1.
DR AlphaFoldDB; Q9T0K9; -.
DR SMR; Q9T0K9; -.
DR STRING; 3702.AT4G13380.1; -.
DR iPTMnet; Q9T0K9; -.
DR PaxDb; Q9T0K9; -.
DR PRIDE; Q9T0K9; -.
DR EnsemblPlants; AT4G13380.1; AT4G13380.1; AT4G13380.
DR GeneID; 826969; -.
DR Gramene; AT4G13380.1; AT4G13380.1; AT4G13380.
DR KEGG; ath:AT4G13380; -.
DR Araport; AT4G13380; -.
DR TAIR; locus:2142070; AT4G13380.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_1398104_0_0_1; -.
DR OMA; KYRSIHA; -.
DR OrthoDB; 1607827at2759; -.
DR PhylomeDB; Q9T0K9; -.
DR PRO; PR:Q9T0K9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9T0K9; baseline.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR CDD; cd00371; HMA; 1.
DR InterPro; IPR044577; HIPP4/7/8/17/18/19.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR46195; PTHR46195; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; SSF55008; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome.
FT CHAIN 1..192
FT /note="Heavy metal-associated isoprenylated plant protein
FT 18"
FT /id="PRO_0000437825"
FT PROPEP 193..195
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437826"
FT DOMAIN 78..149
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REGION 36..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 192
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 192
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 195 AA; 22697 MW; F7CF914E225663CB CRC64;
MVTGNFNLEK LLKNLKKKTG KKAEILTMNE KVEKEDVVQN EANEQETVTK KNEEGDIVDK
KDETPEVEEK IDKPETSTRK LEIHIAFLSE KYEADIGKVI SKFEGVKTCK VDVENKKVVI
TGDFDEEKLW KELEEKMRKR IVKMEKEKKD DEPITKDEEN EIDRGVYMNP SSDDEKEMAR
WMMFSDENPN ACSIS
