ID   HIP19_ARATH             Reviewed;         136 AA.
AC   A0JPW5; Q9LVF6;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Heavy metal-associated isoprenylated plant protein 19 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE            Short=AtHIP19 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE   Flags: Precursor;
GN   Name=HIPP19 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN   OrderedLocusNames=At3g21490 {ECO:0000312|Araport:AT3G21490};
GN   ORFNames=MIL23.6 {ECO:0000312|EMBL:BAB02344.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:ABK32149.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=21072340; DOI=10.1039/c003484c;
RA   Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT   "Metallochaperone-like genes in Arabidopsis thaliana.";
RL   Metallomics 2:556-564(2010).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=23368984; DOI=10.1111/febs.12159;
RA   de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA   Margis-Pinheiro M.;
RT   "Heavy metal-associated isoprenylated plant protein (HIPP):
RT   characterization of a family of proteins exclusive to plants.";
RL   FEBS J. 280:1604-1616(2013).
CC   -!- FUNCTION: Heavy-metal-binding protein. {ECO:0000250|UniProtKB:Q9LZF1}.
CC   -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB02344.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB019232; BAB02344.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE76515.1; -; Genomic_DNA.
DR   EMBL; BT029335; ABK32149.1; -; mRNA.
DR   RefSeq; NP_188786.1; NM_113044.1.
DR   AlphaFoldDB; A0JPW5; -.
DR   SMR; A0JPW5; -.
DR   IntAct; A0JPW5; 5.
DR   STRING; 3702.AT3G21490.1; -.
DR   PaxDb; A0JPW5; -.
DR   PRIDE; A0JPW5; -.
DR   EnsemblPlants; AT3G21490.1; AT3G21490.1; AT3G21490.
DR   GeneID; 821703; -.
DR   Gramene; AT3G21490.1; AT3G21490.1; AT3G21490.
DR   KEGG; ath:AT3G21490; -.
DR   Araport; AT3G21490; -.
DR   TAIR; locus:2089870; AT3G21490.
DR   eggNOG; KOG1603; Eukaryota.
DR   HOGENOM; CLU_100095_2_0_1; -.
DR   InParanoid; A0JPW5; -.
DR   OMA; MNCNACE; -.
DR   OrthoDB; 1548003at2759; -.
DR   PRO; PR:A0JPW5; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; A0JPW5; baseline and differential.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00371; HMA; 1.
DR   InterPro; IPR044577; HIPP4/7/8/17/18/19.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   PANTHER; PTHR46195; PTHR46195; 1.
DR   Pfam; PF00403; HMA; 1.
DR   SUPFAM; SSF55008; SSF55008; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome.
FT   CHAIN           1..133
FT                   /note="Heavy metal-associated isoprenylated plant protein
FT                   19"
FT                   /id="PRO_0000437827"
FT   PROPEP          134..136
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000437828"
FT   DOMAIN          13..77
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         24
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         27
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   MOD_RES         133
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT   LIPID           133
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ   SEQUENCE   136 AA;  15806 MW;  3E09B36DB3B21A8F CRC64;
     MTKDKKKKDN VRYMDVEFNV SMHCNDCERK IARVISKFKG VETFVTDMIN HKVVVRGKID
     PNKLLKKLKK KTGKRVKIVV KEEKGEESSK ENENVLEIDM ESICLGDQSM FGFCDWEMEK
     FMVFSDENVK AICSIS