HIP1_ARATH
ID HIP1_ARATH Reviewed; 245 AA.
AC Q9ZUV1; Q6RF40;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 1 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP01 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Flags: Precursor;
GN Name=HIPP01 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN OrderedLocusNames=At2g28090 {ECO:0000312|Araport:AT2G28090};
GN ORFNames=F24D13.12 {ECO:0000312|EMBL:AAC98457.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-245.
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 75-245.
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- FUNCTION: Heavy-metal-binding protein. {ECO:0000250|UniProtKB:Q9LZF1}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAR99373.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC005851; AAC98457.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08078.1; -; Genomic_DNA.
DR EMBL; AY501361; AAR99373.1; ALT_INIT; mRNA.
DR EMBL; AY924752; AAX23827.1; -; mRNA.
DR PIR; F84680; F84680.
DR RefSeq; NP_180376.1; NM_128369.2.
DR AlphaFoldDB; Q9ZUV1; -.
DR SMR; Q9ZUV1; -.
DR STRING; 3702.AT2G28090.1; -.
DR PaxDb; Q9ZUV1; -.
DR PRIDE; Q9ZUV1; -.
DR EnsemblPlants; AT2G28090.1; AT2G28090.1; AT2G28090.
DR GeneID; 817354; -.
DR Gramene; AT2G28090.1; AT2G28090.1; AT2G28090.
DR KEGG; ath:AT2G28090; -.
DR Araport; AT2G28090; -.
DR TAIR; locus:2046183; AT2G28090.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_039886_3_1_1; -.
DR InParanoid; Q9ZUV1; -.
DR OMA; KIDREME; -.
DR OrthoDB; 1424233at2759; -.
DR PhylomeDB; Q9ZUV1; -.
DR PRO; PR:Q9ZUV1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZUV1; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR InterPro; IPR044594; HIP01/3/5/6.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR46413; PTHR46413; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; SSF55008; 2.
DR PROSITE; PS50846; HMA_2; 2.
PE 2: Evidence at transcript level;
KW Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome;
KW Repeat.
FT CHAIN 1..242
FT /note="Heavy metal-associated isoprenylated plant protein
FT 1"
FT /id="PRO_0000437793"
FT PROPEP 243..245
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437794"
FT DOMAIN 28..92
FT /note="HMA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT DOMAIN 121..188
FT /note="HMA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REGION 91..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 39
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 42
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 132
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 135
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT MOD_RES 242
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 242
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 245 AA; 27468 MW; 81F3ECF91ED46F20 CRC64;
MENPQVCECY HGDVEEEKKK KQNNTTSPVH VVLKIDFHCD GCIARIVRLS RRLEGVETVR
ADPDSNKLTL IGFIMDPVKI AEKLQKKSKK KVELISPKPK KDTKENNEKK ANDKTQTVVA
VTTVVLKVNC SCDGCIKRIQ KAVSTTKGVY QVKMDKEKET VTVMGTMDIK SVTDNLKRKL
KKTVQVVPEK KKKKKDKDNA EVNTKVGSPC QPGNGCTHGI GPYRFMEGPM TGFFSEEDQS
YCSVM
