ID   HIP1_ORYSJ              Reviewed;         667 AA.
AC   Q7XTV7; A0A0P0WFQ0; C7J171;
DT   11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Probable E3 ubiquitin-protein ligase HIP1;
DE            EC=2.3.2.27;
DE   AltName: Full=HAL3-interacting protein 1;
DE            Short=OsHIP1;
DE   AltName: Full=RING-H2 finger HIP1;
DE   AltName: Full=RING-type E3 ubiquitin transferase HIP1 {ECO:0000305};
GN   Name=HIP1; OrderedLocusNames=Os04g0648800, LOC_Os04g55510;
GN   ORFNames=OsJ_16417, OSJNBa0010D21.9;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA   Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA   Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA   Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA   Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA   Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA   Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA   Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA   Li J., Hong G., Xue Y., Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [7]
RP   FUNCTION, INTERACTION WITH HAL3, AND INDUCTION BY PANTOTHENATE.
RX   PubMed=19543273; DOI=10.1038/ncb1892;
RA   Sun S.Y., Chao D.Y., Li X.M., Shi M., Gao J.P., Zhu M.Z., Yang H.Q.,
RA   Luan S., Lin H.X.;
RT   "OsHAL3 mediates a new pathway in the light-regulated growth of rice.";
RL   Nat. Cell Biol. 11:845-851(2009).
CC   -!- FUNCTION: Probable E3 ubiquitin-protein ligase that functions
CC       downstream of HAL3 and is required for HAL3-regulated plant growth.
CC       Activation of HIP1 by HAL3 may lead to the degradation of cell cycle
CC       suppressors, resulting in enhancement of cell division and plant
CC       growth. {ECO:0000269|PubMed:19543273}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27;
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with HAL3. {ECO:0000269|PubMed:19543273}.
CC   -!- INDUCTION: By pantothenate. {ECO:0000269|PubMed:19543273}.
CC   -!- DOMAIN: The RING-type zinc finger domain mediates binding to an E2
CC       ubiquitin-conjugating enzyme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RING-type zinc finger family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAH92849.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL606635; CAD41707.2; -; Genomic_DNA.
DR   EMBL; AP008210; BAH92849.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014960; BAS91331.1; -; Genomic_DNA.
DR   EMBL; CM000141; EAZ32210.1; -; Genomic_DNA.
DR   EMBL; AK071468; BAG92508.1; -; mRNA.
DR   RefSeq; XP_015636255.1; XM_015780769.1.
DR   AlphaFoldDB; Q7XTV7; -.
DR   SMR; Q7XTV7; -.
DR   STRING; 4530.OS04T0648800-01; -.
DR   PaxDb; Q7XTV7; -.
DR   PRIDE; Q7XTV7; -.
DR   EnsemblPlants; Os04t0648800-01; Os04t0648800-01; Os04g0648800.
DR   GeneID; 9272591; -.
DR   Gramene; Os04t0648800-01; Os04t0648800-01; Os04g0648800.
DR   KEGG; osa:9272591; -.
DR   eggNOG; KOG0800; Eukaryota.
DR   HOGENOM; CLU_024479_0_0_1; -.
DR   InParanoid; Q7XTV7; -.
DR   OMA; CWNNLRN; -.
DR   OrthoDB; 301445at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000000763; Chromosome 4.
DR   Proteomes; UP000007752; Chromosome 4.
DR   Proteomes; UP000059680; Chromosome 4.
DR   ExpressionAtlas; Q7XTV7; baseline and differential.
DR   Genevisible; Q7XTV7; OS.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0044260; P:cellular macromolecule metabolic process; IEA:UniProt.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR045191; MBR1/2-like.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22937; PTHR22937; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   Growth regulation; Metal-binding; Reference proteome; Transferase;
KW   Ubl conjugation pathway; Zinc; Zinc-finger.
FT   CHAIN           1..667
FT                   /note="Probable E3 ubiquitin-protein ligase HIP1"
FT                   /id="PRO_0000429415"
FT   ZN_FING         620..661
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          142..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  72641 MW;  7C815021E6CEF3EC CRC64;
     MQGQKNSVEQ LADVFGFDHA SSSGNPVMDQ QGYWNNILGS VESHNLQGYQ VNRSDGTIPY
     GNGVHQNGTF LGFWESGEAS ASGSSLHFGG SNEIKAEQRN IGGGLRIGER RLVAERNLSL
     DNVDIGLNIN GNDLSGENSN VNGASQGSEL HGGCSHTGSN GQASELRLHP YRTFILGADQ
     PEPFNSLNGS ENPLGDFSLM PEGIDQRPGS SLDGRRLACK RKNIEGVNGQ CSAGASTSFS
     HRNDSIFHNI ASSSHNPSPS TNLPSPNCLL VPSTLDEQLP RYGATTAGLS SSSYDPSGGN
     NNSGGSQRSF RPRTSLAQHI GPYGVWPSSS TIRHSNSWNH QPPPFQSSFD EPPEVIPVVS
     SLNFQYQHPM NVVPGIPQMS HRFTGPGASS SRTGNLENRI IGSEEFSARN VVATSFPDAV
     PPAALDMRHL IPEPSSWNVD GRATTIPGNV PSSSRANTNS MVNPPAGSPF IAHQNLHRRN
     PRNLSEEISR LSGALRGHQH PRLRSGFLLE RQGDGVWGVP LSTRSREGRR LIEIRNALEM
     IHRGENVRFE SIFYGGVDIH DRHRDMRLDI DNMSYEELLA LEERIGNVST GLSEEEVTKL
     LKQRKFSSWR LEASVEEEPC CICQEEYVDG DDLGTLDCGH DFHVGCVRQW LVVKNTCPIC
     KNTALKS