HIP27_ARATH
ID HIP27_ARATH Reviewed; 147 AA.
AC Q67ZW1; Q9FKX1;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 27 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP27 {ECO:0000303|PubMed:23368984};
DE Short=AtHIPP27 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Flags: Precursor;
GN Name=HIPP27 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN OrderedLocusNames=At5g66110 {ECO:0000312|Araport:AT5G66110};
GN ORFNames=K2A18.19 {ECO:0000312|EMBL:BAB10416.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-147.
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH ZHD11/HB29.
RC STRAIN=cv. Columbia;
RX PubMed=18974936; DOI=10.1007/s11103-008-9419-0;
RA Barth O., Vogt S., Uhlemann R., Zschiesche W., Humbeck K.;
RT "Stress induced and nuclear localized HIPP26 from Arabidopsis thaliana
RT interacts via its heavy metal associated domain with the drought stress
RT related zinc finger transcription factor ATHB29.";
RL Plant Mol. Biol. 69:213-226(2009).
RN [6]
RP NOMENCLATURE, AND GENE FAMILY.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
RN [8]
RP INTERACTION WITH UBP16.
RX PubMed=23857362; DOI=10.4161/psb.25680;
RA Zhao J., Zhou H., Li Y.;
RT "UBIQUITIN-SPECIFIC PROTEASE16 interacts with a HEAVY METAL ASSOCIATED
RT ISOPRENYLATED PLANT PROTEIN27 and modulates cadmium tolerance.";
RL Plant Signal. Behav. 8:E25680-E25680(2013).
CC -!- FUNCTION: Heavy-metal-binding protein. Binds cadmium. May be involved
CC in cadmium transport and play a role in cadmium detoxification.
CC {ECO:0000250|UniProtKB:Q9C9A3}.
CC -!- SUBUNIT: Interacts with UBP16 (PubMed:23857362). Interacts with
CC ZHD11/HB29 (PubMed:18974936). {ECO:0000269|PubMed:18974936,
CC ECO:0000269|PubMed:23857362}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9SZN7}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB10416.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB011474; BAB10416.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED98160.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70586.1; -; Genomic_DNA.
DR EMBL; AK175898; BAD43661.1; -; mRNA.
DR EMBL; AK176006; BAD43769.1; -; mRNA.
DR EMBL; BT010626; AAQ89648.1; -; mRNA.
DR RefSeq; NP_001332182.1; NM_001345746.1.
DR RefSeq; NP_001332183.1; NM_001345747.1.
DR RefSeq; NP_201412.2; NM_126009.3.
DR AlphaFoldDB; Q67ZW1; -.
DR SMR; Q67ZW1; -.
DR IntAct; Q67ZW1; 4.
DR STRING; 3702.AT5G66110.1; -.
DR PaxDb; Q67ZW1; -.
DR PRIDE; Q67ZW1; -.
DR ProteomicsDB; 230345; -.
DR DNASU; 836743; -.
DR EnsemblPlants; AT5G66110.1; AT5G66110.1; AT5G66110.
DR EnsemblPlants; AT5G66110.3; AT5G66110.3; AT5G66110.
DR GeneID; 836743; -.
DR Gramene; AT5G66110.1; AT5G66110.1; AT5G66110.
DR Gramene; AT5G66110.3; AT5G66110.3; AT5G66110.
DR KEGG; ath:AT5G66110; -.
DR Araport; AT5G66110; -.
DR TAIR; locus:2156927; AT5G66110.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_100095_1_0_1; -.
DR InParanoid; Q67ZW1; -.
DR OMA; GMKGVTK; -.
DR OrthoDB; 1405845at2759; -.
DR PhylomeDB; Q67ZW1; -.
DR PRO; PR:Q67ZW1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q67ZW1; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd00371; HMA; 1.
DR InterPro; IPR045181; HIPP/ATX1-like.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR22814; PTHR22814; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; SSF55008; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 1: Evidence at protein level;
KW Cadmium; Lipoprotein; Membrane; Metal-binding; Methylation; Prenylation;
KW Reference proteome.
FT CHAIN 1..144
FT /note="Heavy metal-associated isoprenylated plant protein
FT 27"
FT /id="PRO_0000435863"
FT PROPEP 145..147
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000435864"
FT DOMAIN 18..82
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 29
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 32
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT MOD_RES 144
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 144
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 147 AA; 16651 MW; 4808F05FA8D354DF CRC64;
MGFRDICYRK HHKKLKQFQK VEIKVKMDCE GCERRVRKSV EGMKGVSKVT VDPKQSKLTV
EGFVQPSKVV HRVMHRTGKK AELWPYVPYE VVPHPYAPGA YDKKAPPGYV RNALADPLVA
PLARASSFEV KYTSAFSDDN PNACTIM
