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HIP33_ARATH
ID   HIP33_ARATH             Reviewed;         587 AA.
AC   F4JZL7; F4JZL8; Q84WQ1;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Heavy metal-associated isoprenylated plant protein 33 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE            Short=AtHIP33 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE   Flags: Precursor;
GN   Name=HIPP33 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN   OrderedLocusNames=At5g19090 {ECO:0000312|Araport:AT5G19090};
GN   ORFNames=T16G12.130 {ECO:0000312|EMBL:AC068809};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 115-587.
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=21072340; DOI=10.1039/c003484c;
RA   Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT   "Metallochaperone-like genes in Arabidopsis thaliana.";
RL   Metallomics 2:556-564(2010).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=23368984; DOI=10.1111/febs.12159;
RA   de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA   Margis-Pinheiro M.;
RT   "Heavy metal-associated isoprenylated plant protein (HIPP):
RT   characterization of a family of proteins exclusive to plants.";
RL   FEBS J. 280:1604-1616(2013).
CC   -!- FUNCTION: Heavy-metal-binding protein. {ECO:0000250|UniProtKB:Q9LZF1}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=F4JZL7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=F4JZL7-2; Sequence=VSP_058571;
CC   -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
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DR   EMBL; AC068809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED92650.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED92651.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED92652.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM69822.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM69823.1; -; Genomic_DNA.
DR   EMBL; BT002910; AAO22726.1; -; mRNA.
DR   RefSeq; NP_001154719.1; NM_001161247.1. [F4JZL7-2]
DR   RefSeq; NP_001331474.1; NM_001343588.1. [F4JZL7-1]
DR   RefSeq; NP_001331475.1; NM_001343587.1. [F4JZL7-1]
DR   RefSeq; NP_197410.1; NM_121914.4. [F4JZL7-1]
DR   RefSeq; NP_850851.1; NM_180520.2. [F4JZL7-2]
DR   AlphaFoldDB; F4JZL7; -.
DR   SMR; F4JZL7; -.
DR   STRING; 3702.AT5G19090.1; -.
DR   PaxDb; F4JZL7; -.
DR   PRIDE; F4JZL7; -.
DR   ProteomicsDB; 230193; -. [F4JZL7-1]
DR   EnsemblPlants; AT5G19090.1; AT5G19090.1; AT5G19090. [F4JZL7-1]
DR   EnsemblPlants; AT5G19090.2; AT5G19090.2; AT5G19090. [F4JZL7-2]
DR   EnsemblPlants; AT5G19090.3; AT5G19090.3; AT5G19090. [F4JZL7-2]
DR   EnsemblPlants; AT5G19090.4; AT5G19090.4; AT5G19090. [F4JZL7-1]
DR   EnsemblPlants; AT5G19090.5; AT5G19090.5; AT5G19090. [F4JZL7-1]
DR   GeneID; 832028; -.
DR   Gramene; AT5G19090.1; AT5G19090.1; AT5G19090. [F4JZL7-1]
DR   Gramene; AT5G19090.2; AT5G19090.2; AT5G19090. [F4JZL7-2]
DR   Gramene; AT5G19090.3; AT5G19090.3; AT5G19090. [F4JZL7-2]
DR   Gramene; AT5G19090.4; AT5G19090.4; AT5G19090. [F4JZL7-1]
DR   Gramene; AT5G19090.5; AT5G19090.5; AT5G19090. [F4JZL7-1]
DR   KEGG; ath:AT5G19090; -.
DR   Araport; AT5G19090; -.
DR   TAIR; locus:2179604; AT5G19090.
DR   eggNOG; KOG1603; Eukaryota.
DR   InParanoid; F4JZL7; -.
DR   OMA; GPPMKMG; -.
DR   OrthoDB; 1550780at2759; -.
DR   PRO; PR:F4JZL7; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4JZL7; baseline and differential.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00371; HMA; 1.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   Pfam; PF00403; HMA; 1.
DR   SUPFAM; SSF55008; SSF55008; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Lipoprotein; Metal-binding; Methylation; Prenylation;
KW   Reference proteome.
FT   CHAIN           1..584
FT                   /note="Heavy metal-associated isoprenylated plant protein
FT                   33"
FT                   /id="PRO_0000437843"
FT   PROPEP          585..587
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000437844"
FT   DOMAIN          9..72
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   REGION          98..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..587
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..248
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..566
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..587
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         20
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         23
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   MOD_RES         584
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT   LIPID           584
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT   VAR_SEQ         291..412
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_058571"
SQ   SEQUENCE   587 AA;  59621 MW;  08C058F7B0953C93 CRC64;
     MSKEEFMKIQ TCVLKVNIHC DGCKQKVKKI LQKIEGVFTT KIDAELGKVT VSGNVDPSVL
     IKKLLKSGKH AEIWGAPKGG SNNNQNQPNL ANQFKAMQID HGGKGGGGGG GGPANNNKGQ
     KIGGGGGGGG GGGGGGGGGP PKMVIPQLTP QQMQQLNPQQ LQQLQQLQQM KGFQDLKLPP
     QLKGGPGPGP GSVPMNKNPQ MPNNPNQKAV KFNVPDDDDE EDFSDEFDDE FDEDDDEFDD
     DLEDDEFDDH PPPPNKMKPM MGGGNMIMPN NMMPNMMMPN AQQMLNAHKN GGGPGPAGGK
     IEGKGMPFPV QMGGGGGGPG GKKGGPGGGG GNMGNQNQGG GGKNGGKGGG GHPLDGKMGG
     GGGGPNGNKG GGGVQMNGGP NGGKKGGGGG GGGGGGPMSG GLPPGFRPMG GGGGGGGGPQ
     SMSMPMGGAM GGPMGSLPQM GGGPGPMSNN MQAVQGLPAM GPGGGGGGGP SAEAPPGYFQ
     GQVSGNGGGG QDSMPGNPYL QQQQQQQQQQ YLAAVMNQQR SMGNERFQPM MYARPPPAVN
     YMPPQPQPHQ QHPYPYPYPY PPQYPPHNGD QYSDYFNDEN TSSCNIM
 
 
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