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HIP39_ARATH
ID   HIP39_ARATH             Reviewed;         177 AA.
AC   O03982; Q7DLT7; Q9LMN0;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Heavy metal-associated isoprenylated plant protein 39 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE            Short=AtHIP39 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE   Flags: Precursor;
GN   Name=HIPP39 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN   OrderedLocusNames=At1g01490 {ECO:0000312|Araport:AT1G01490};
GN   ORFNames=F22L4.5 {ECO:0000312|EMBL:AAF81309.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:CAA71173.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9666060; DOI=10.1016/s0378-1119(98)00286-8;
RA   Terryn N., Gielen J., De Keyser A., Van Den Daele H., Ardiles W., Neyt P.,
RA   De Clercq R., Coppieters J., Dehais P., Villarroel R., Rouze P.,
RA   van Montagu M.;
RT   "Sequence analysis of a 40-kb Arabidopsis thaliana genomic region located
RT   at the top of chromosome 1.";
RL   Gene 215:11-17(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=21072340; DOI=10.1039/c003484c;
RA   Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT   "Metallochaperone-like genes in Arabidopsis thaliana.";
RL   Metallomics 2:556-564(2010).
RN   [6]
RP   GENE FAMILY, NOMENCLATURE, AND INDUCTION BY CADMIUM.
RX   PubMed=23368984; DOI=10.1111/febs.12159;
RA   de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA   Margis-Pinheiro M.;
RT   "Heavy metal-associated isoprenylated plant protein (HIPP):
RT   characterization of a family of proteins exclusive to plants.";
RL   FEBS J. 280:1604-1616(2013).
CC   -!- FUNCTION: Probable heavy-metal-binding protein.
CC       {ECO:0000250|UniProtKB:Q9LZF1}.
CC   -!- INDUCTION: Up-regulated by cadmium. {ECO:0000303|PubMed:23368984}.
CC   -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC   -!- CAUTION: The HMA domain lacks the core conserved Cys-X-X-Cys motif.
CC       {ECO:0000305|PubMed:21072340}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF81309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; Y10083; CAA71172.1; -; Genomic_DNA.
DR   EMBL; Y10084; CAA71173.1; -; Genomic_DNA.
DR   EMBL; AC061957; AAF81309.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE27295.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE27296.1; -; Genomic_DNA.
DR   EMBL; AY063805; AAL36161.1; -; mRNA.
DR   EMBL; AY091276; AAM14215.1; -; mRNA.
DR   PIR; F86145; F86145.
DR   RefSeq; NP_001030928.1; NM_001035851.2.
DR   RefSeq; NP_171656.1; NM_100031.5.
DR   AlphaFoldDB; O03982; -.
DR   SMR; O03982; -.
DR   STRING; 3702.AT1G01490.1; -.
DR   PaxDb; O03982; -.
DR   PRIDE; O03982; -.
DR   ProteomicsDB; 230207; -.
DR   EnsemblPlants; AT1G01490.1; AT1G01490.1; AT1G01490.
DR   EnsemblPlants; AT1G01490.2; AT1G01490.2; AT1G01490.
DR   GeneID; 839440; -.
DR   Gramene; AT1G01490.1; AT1G01490.1; AT1G01490.
DR   Gramene; AT1G01490.2; AT1G01490.2; AT1G01490.
DR   KEGG; ath:AT1G01490; -.
DR   Araport; AT1G01490; -.
DR   TAIR; locus:2025421; AT1G01490.
DR   eggNOG; KOG1603; Eukaryota.
DR   HOGENOM; CLU_092610_3_0_1; -.
DR   InParanoid; O03982; -.
DR   OMA; CWHTDIL; -.
DR   PhylomeDB; O03982; -.
DR   PRO; PR:O03982; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; O03982; baseline and differential.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   Pfam; PF00403; HMA; 1.
DR   SUPFAM; SSF55008; SSF55008; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome.
FT   CHAIN           1..174
FT                   /note="Heavy metal-associated isoprenylated plant protein
FT                   39"
FT                   /id="PRO_0000437853"
FT   PROPEP          175..177
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000437854"
FT   DOMAIN          1..68
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   REGION          70..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..129
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         174
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT   LIPID           174
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ   SEQUENCE   177 AA;  19781 MW;  3B97B37D3C62336D CRC64;
     MKKIVLKLDL HDDRAKQKAL KTVSTLPGID SIAMDMKEKK LTVIGTVDPV NVVSKLRKYW
     PMTDIVLVGP AKEPEKEKKE EPKKEGGGEP PKKEGEAPKE EGKKEGEAPK KEEEKKEGGD
     KKEGEKKDQP QAQPQPVVPP PDHVLELVKA YKAYNPHLTT YYYAQSIEEN PNACVIC
 
 
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