ID   HIP41_ARATH             Reviewed;         515 AA.
AC   F4I1X0; A0A2H1ZEE4; F4I1X1; Q9LFZ4; Q9LG34; Q9LG35;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Heavy metal-associated isoprenylated plant protein 41 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE            Short=AtHIP41 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE   Flags: Precursor;
GN   Name=HIPP41 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN   OrderedLocusNames=At1g55790 {ECO:0000312|Araport:AT1G55790};
GN   ORFNames=F14J16.2 {ECO:0000312|EMBL:AAF79341.1},
GN   F14J16.3 {ECO:0000312|EMBL:AAF79340.1},
GN   F20N2.17 {ECO:0000312|EMBL:AAF79501.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=21072340; DOI=10.1039/c003484c;
RA   Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT   "Metallochaperone-like genes in Arabidopsis thaliana.";
RL   Metallomics 2:556-564(2010).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=23368984; DOI=10.1111/febs.12159;
RA   de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA   Margis-Pinheiro M.;
RT   "Heavy metal-associated isoprenylated plant protein (HIPP):
RT   characterization of a family of proteins exclusive to plants.";
RL   FEBS J. 280:1604-1616(2013).
CC   -!- FUNCTION: Heavy-metal-binding protein. {ECO:0000250|UniProtKB:Q9LZF1}.
CC   -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF79340.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAF79341.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAF79501.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AEE33296.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC002304; AAF79340.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC002304; AAF79341.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC002328; AAF79501.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE33296.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_564700.3; NM_104455.4.
DR   AlphaFoldDB; F4I1X0; -.
DR   STRING; 3702.AT1G55790.1; -.
DR   PaxDb; F4I1X0; -.
DR   PRIDE; F4I1X0; -.
DR   ProteomicsDB; 230241; -.
DR   EnsemblPlants; AT1G55790.1; AT1G55790.1; AT1G55790.
DR   GeneID; 842028; -.
DR   Gramene; AT1G55790.1; AT1G55790.1; AT1G55790.
DR   KEGG; ath:AT1G55790; -.
DR   Araport; AT1G55790; -.
DR   TAIR; locus:2012105; AT1G55790.
DR   eggNOG; KOG4174; Eukaryota.
DR   HOGENOM; CLU_529320_0_0_1; -.
DR   InParanoid; F4I1X0; -.
DR   OrthoDB; 1082498at2759; -.
DR   PRO; PR:F4I1X0; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; F4I1X0; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070042; F:rRNA (uridine-N3-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0070475; P:rRNA base methylation; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR019446; BMT5-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF10354; DUF2431; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
KW   Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome.
FT   CHAIN           1..512
FT                   /note="Heavy metal-associated isoprenylated plant protein
FT                   41"
FT                   /id="PRO_0000437855"
FT   PROPEP          513..515
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000437856"
FT   DOMAIN          376..444
FT                   /note="HMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   MOD_RES         512
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT   LIPID           512
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ   SEQUENCE   515 AA;  59038 MW;  F0D90367D1C3CA46 CRC64;
     MAMRELSQLN RDSDGDEEVW VKHYSSNHQI LLVGEGDFSF SHSLATLFGS ASNICASSLD
     SYDVVVRKYK KARSNLKTLK RLGALLLHGV DATTLHFHPD LRYRRFDRVI FNFPHAGFHG
     RESDSSLIRK HRELVFGFFN GASRLLRANG EVHVSHKNKA PFSEWNLEEL ASRCFLVLIQ
     RVAFEKNNYP GYENKRGDGR RCDQPFLLGE CSTFKFRFSR VAKELYAEKV RSREVKERES
     MYPEAILNKQ PVSFDHRYRL QTEFEAIAGT ITLGKSKILW LSQEKGHLHW IFVTTKNVDV
     YSSKIPVFLI CTLESRQRDI ACFVKTFQFK LVKNHYPNTL TAGVEFLVKF ITGKYEECQQ
     VTYLRKNFSG YGDGNKQRIV LKMDMSDEKS MKKAMKIASA KPGVRSVSIQ GQNDQLVLLG
     EGIDLAELTR ELKKKVCMTT IITVQAAPPQ QPPQPHPMGQ YNQMPPARRC TCEIPNSGFC
     GFCRSMSQPN YQVVPSPYYP PMLYCRDETD GCRIL