HIP42_ARATH
ID HIP42_ARATH Reviewed; 208 AA.
AC Q9CAV5;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Heavy metal-associated isoprenylated plant protein 42 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Short=AtHIP42 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE Flags: Precursor;
GN Name=HIPP42 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN OrderedLocusNames=At3g04900 {ECO:0000312|Araport:AT3G04900};
GN ORFNames=T9J14.15 {ECO:0000312|EMBL:AAG51419.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21072340; DOI=10.1039/c003484c;
RA Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT "Metallochaperone-like genes in Arabidopsis thaliana.";
RL Metallomics 2:556-564(2010).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=23368984; DOI=10.1111/febs.12159;
RA de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA Margis-Pinheiro M.;
RT "Heavy metal-associated isoprenylated plant protein (HIPP):
RT characterization of a family of proteins exclusive to plants.";
RL FEBS J. 280:1604-1616(2013).
CC -!- FUNCTION: Probable heavy-metal-binding protein.
CC {ECO:0000250|UniProtKB:Q9LZF1}.
CC -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
CC -!- CAUTION: The HMA domain lacks the core conserved Cys-X-X-Cys motif.
CC {ECO:0000305|PubMed:21072340}.
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DR EMBL; AC009465; AAG51419.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74153.1; -; Genomic_DNA.
DR RefSeq; NP_187141.1; NM_111362.2.
DR AlphaFoldDB; Q9CAV5; -.
DR SMR; Q9CAV5; -.
DR STRING; 3702.AT3G04900.1; -.
DR PaxDb; Q9CAV5; -.
DR PRIDE; Q9CAV5; -.
DR DNASU; 819650; -.
DR EnsemblPlants; AT3G04900.1; AT3G04900.1; AT3G04900.
DR GeneID; 819650; -.
DR Gramene; AT3G04900.1; AT3G04900.1; AT3G04900.
DR KEGG; ath:AT3G04900; -.
DR Araport; AT3G04900; -.
DR TAIR; locus:2114860; AT3G04900.
DR eggNOG; KOG1603; Eukaryota.
DR HOGENOM; CLU_1391955_0_0_1; -.
DR InParanoid; Q9CAV5; -.
DR OMA; CCKGCAT; -.
DR OrthoDB; 1364424at2759; -.
DR PRO; PR:Q9CAV5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9CAV5; differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; SSF55008; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW Lipoprotein; Metal-binding; Methylation; Prenylation; Reference proteome.
FT CHAIN 1..205
FT /note="Heavy metal-associated isoprenylated plant protein
FT 42"
FT /id="PRO_0000437857"
FT PROPEP 206..208
FT /note="Removed in mature form"
FT /evidence="ECO:0000305"
FT /id="PRO_0000437858"
FT DOMAIN 6..70
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REGION 93..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 205
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT LIPID 205
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ SEQUENCE 208 AA; 23043 MW; E20CEB6180B907F5 CRC64;
MEDLDFPICI LKMNLQCCED FPSRVKKLLR QVKGVYAITI DPVKGLILVC GTAEPSVLIK
AVAKLGQSPQ LYAYEKDPAT AKTRFRTLLK RYATNKTQDK PSPPAPPVTA TTPVETCPAG
GETFRGFGYP GPTTMMQMPA FSLPPPRGLP GWLAPPTNPR LKYEEPKVTP RKPPAPYPFD
YYENLGFPPS DSLFNYFSDD NPQPCSIM
