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HIP4_ARATH
ID   HIP4_ARATH              Reviewed;         287 AA.
AC   Q9SHQ8;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Heavy metal-associated isoprenylated plant protein 4 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE            Short=AtHIP04 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
DE   Flags: Precursor;
GN   Name=HIPP04 {ECO:0000303|PubMed:21072340, ECO:0000303|PubMed:23368984};
GN   OrderedLocusNames=At1g29000 {ECO:0000312|Araport:AT1G29000};
GN   ORFNames=F1K23.4 {ECO:0000312|EMBL:AAF24557.2};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=21072340; DOI=10.1039/c003484c;
RA   Tehseen M., Cairns N., Sherson S., Cobbett C.S.;
RT   "Metallochaperone-like genes in Arabidopsis thaliana.";
RL   Metallomics 2:556-564(2010).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=23368984; DOI=10.1111/febs.12159;
RA   de Abreu-Neto J.B., Turchetto-Zolet A.C., de Oliveira L.F., Zanettini M.H.,
RA   Margis-Pinheiro M.;
RT   "Heavy metal-associated isoprenylated plant protein (HIPP):
RT   characterization of a family of proteins exclusive to plants.";
RL   FEBS J. 280:1604-1616(2013).
CC   -!- FUNCTION: Heavy-metal-binding protein. {ECO:0000250|UniProtKB:Q9LZF1}.
CC   -!- SIMILARITY: Belongs to the HIPP family. {ECO:0000305}.
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DR   EMBL; AC007508; AAF24557.2; -; Genomic_DNA.
DR   EMBL; CP002684; AEE31027.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM58287.1; -; Genomic_DNA.
DR   RefSeq; NP_001319102.1; NM_001332827.1.
DR   RefSeq; NP_174195.1; NM_102641.2.
DR   AlphaFoldDB; Q9SHQ8; -.
DR   SMR; Q9SHQ8; -.
DR   STRING; 3702.AT1G29000.1; -.
DR   SwissPalm; Q9SHQ8; -.
DR   PaxDb; Q9SHQ8; -.
DR   PRIDE; Q9SHQ8; -.
DR   ProteomicsDB; 230365; -.
DR   EnsemblPlants; AT1G29000.1; AT1G29000.1; AT1G29000.
DR   EnsemblPlants; AT1G29000.2; AT1G29000.2; AT1G29000.
DR   GeneID; 839774; -.
DR   Gramene; AT1G29000.1; AT1G29000.1; AT1G29000.
DR   Gramene; AT1G29000.2; AT1G29000.2; AT1G29000.
DR   KEGG; ath:AT1G29000; -.
DR   Araport; AT1G29000; -.
DR   TAIR; locus:2018768; AT1G29000.
DR   eggNOG; KOG1603; Eukaryota.
DR   HOGENOM; CLU_039886_3_1_1; -.
DR   InParanoid; Q9SHQ8; -.
DR   OMA; LHCPQCA; -.
DR   OrthoDB; 1487073at2759; -.
DR   PhylomeDB; Q9SHQ8; -.
DR   PRO; PR:Q9SHQ8; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9SHQ8; baseline and differential.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00371; HMA; 1.
DR   InterPro; IPR044577; HIPP4/7/8/17/18/19.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   PANTHER; PTHR46195; PTHR46195; 2.
DR   Pfam; PF00403; HMA; 2.
DR   SUPFAM; SSF55008; SSF55008; 2.
DR   PROSITE; PS50846; HMA_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Lipoprotein; Metal-binding; Methylation; Prenylation;
KW   Reference proteome; Repeat; Zinc.
FT   CHAIN           1..284
FT                   /note="Heavy metal-associated isoprenylated plant protein
FT                   4"
FT                   /id="PRO_0000437797"
FT   PROPEP          285..287
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000437798"
FT   DOMAIN          14..80
FT                   /note="HMA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   DOMAIN          112..176
FT                   /note="HMA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   REGION          181..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          179..235
FT                   /evidence="ECO:0000255"
FT   BINDING         25
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         28
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         123
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   BINDING         126
FT                   /ligand="a metal cation"
FT                   /ligand_id="ChEBI:CHEBI:25213"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT   MOD_RES         284
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
FT   LIPID           284
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9SZN7"
SQ   SEQUENCE   287 AA;  33411 MW;  7F59DE19A6F4E85A CRC64;
     MGEEEEKKEK GDEIITAVYK VHLHCRKCAC DIKKPLLRFQ GVQNVDFDLE KNEIKVKGKI
     EVVKIHKQIE KWSKKKVELI SPKPSEVKKT TTTTTTTSVV EKKTTEIKKD VIRTTVLKVH
     IHCAQCDKDL QHKLLKHKAI HIVKTDTKAQ TLTVQGTIES AKLLAYIKKK VHKHAEIISS
     KTEEEKKKEE EDKKKKEEED KKKKEDEKKK EEEKKKEEEN KKKEGEKKKE EVKVEVTTKT
     ITQVVEYKEI VKVEGQKDKD GNIPYFVHYV YAPQLFSDEN PNACRIV
 
 
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