HIPL1_MOUSE
ID HIPL1_MOUSE Reviewed; 791 AA.
AC Q14DK5; Q14CI0; Q3UGD3; Q3UU97; Q6ZPH6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=HHIP-like protein 1;
DE Flags: Precursor;
GN Name=Hhipl1; Synonyms=Hhip2, Kiaa1822;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-791 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-791 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-791 (ISOFORM 1).
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14DK5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14DK5-2; Sequence=VSP_030457, VSP_030458;
CC -!- SIMILARITY: Belongs to the HHIP family. {ECO:0000305}.
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DR EMBL; BC113163; AAI13164.1; -; mRNA.
DR EMBL; BC113773; AAI13774.1; -; mRNA.
DR EMBL; AK138646; BAE23730.1; -; mRNA.
DR EMBL; AK147996; BAE28276.1; -; mRNA.
DR EMBL; AK129450; BAC98260.1; -; mRNA.
DR CCDS; CCDS36554.1; -. [Q14DK5-1]
DR RefSeq; NP_001037845.1; NM_001044380.1. [Q14DK5-1]
DR RefSeq; XP_006515728.1; XM_006515665.3. [Q14DK5-2]
DR AlphaFoldDB; Q14DK5; -.
DR SMR; Q14DK5; -.
DR STRING; 10090.ENSMUSP00000021685; -.
DR GlyGen; Q14DK5; 3 sites.
DR iPTMnet; Q14DK5; -.
DR PhosphoSitePlus; Q14DK5; -.
DR PaxDb; Q14DK5; -.
DR PRIDE; Q14DK5; -.
DR ProteomicsDB; 269754; -. [Q14DK5-1]
DR ProteomicsDB; 269755; -. [Q14DK5-2]
DR Antibodypedia; 57719; 59 antibodies from 16 providers.
DR Ensembl; ENSMUST00000021685; ENSMUSP00000021685; ENSMUSG00000021260. [Q14DK5-1]
DR GeneID; 214305; -.
DR KEGG; mmu:214305; -.
DR UCSC; uc007ozn.1; mouse. [Q14DK5-1]
DR CTD; 84439; -.
DR MGI; MGI:1919265; Hhipl1.
DR VEuPathDB; HostDB:ENSMUSG00000021260; -.
DR eggNOG; ENOG502QQKP; Eukaryota.
DR GeneTree; ENSGT00940000162083; -.
DR HOGENOM; CLU_012344_2_3_1; -.
DR InParanoid; Q14DK5; -.
DR OMA; HEWIRIS; -.
DR OrthoDB; 728630at2759; -.
DR PhylomeDB; Q14DK5; -.
DR TreeFam; TF329059; -.
DR BioGRID-ORCS; 214305; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Hhipl1; mouse.
DR PRO; PR:Q14DK5; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q14DK5; protein.
DR Bgee; ENSMUSG00000021260; Expressed in decidua and 79 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR Gene3D; 3.10.250.10; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR018143; Folate_rcpt-like.
DR InterPro; IPR012938; Glc/Sorbosone_DH.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR Pfam; PF03024; Folate_rec; 1.
DR Pfam; PF07995; GSDH; 1.
DR Pfam; PF00530; SRCR; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 1.
DR SUPFAM; SSF50952; SSF50952; 1.
DR SUPFAM; SSF56487; SSF56487; 1.
DR PROSITE; PS00420; SRCR_1; 1.
DR PROSITE; PS50287; SRCR_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..791
FT /note="HHIP-like protein 1"
FT /id="PRO_0000314963"
FT DOMAIN 682..785
FT /note="SRCR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT REGION 610..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..652
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..667
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 240
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 461
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 679
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 187..527
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 191..534
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 405..423
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 490..590
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 709..774
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 722..784
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 754..764
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT VAR_SEQ 583..645
FT /note="RRAPPGKCKIRPAQVKVRSHLIPFVPKEKFIRTPESTPRPTARAPTKAPRRR
FT RPTAAPPAPTP -> SVLPDTHTSDACQLTRGKGGHGGRPRGHSLNRTTVVFCLVLNII
FT SLRDGTLSCFLDLPEMQTQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030457"
FT VAR_SEQ 646..791
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030458"
FT CONFLICT 68
FT /note="V -> A (in Ref. 1; AAI13774)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="R -> H (in Ref. 1; AAI13774)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 791 AA; 87528 MW; A5F904AFE66AD21F CRC64;
MAGRRAVARI GPGALLVLRA LLAAAHPQCL DFRPPFRPPQ PLSFCAQYSA FGCCTAEQDA
ALARRFRVLE TRMDAGVWAT CAGYALDLLC QECSPYAAHL YDAEDPATPL RTVPGLCEDY
CLDMWQTCRG LFRLLSPDRE LWALESNRAK LCRYLSLDDT DYCFPSLLVN ENLNSNLGRV
VADAKGCLQL CLEEVANGLR NPVAMVHAGD GSHRFFVAEQ VGLVWTYLPD RSRLEKPFLN
VSQAVLTSPW EGDERGFLGL AFHPRFPHPS KLYVYYSVGV GFREWIRISE FRVSEGDENT
VDHGSERIIL EIEEPASNHN GGQLLFGDDG FLYIFTGDGG MAGDPFGKFG NAQNKSALLG
KVLRIDVDRK ERGLHYGIPP DNPFVDDPGA RPEVYALGVR NMWRCSFDRG DPMSGTGRGR
LFCGDVGQNK YEEVDLVERG RNYGWRAREG FECYDRKLCA NTSLDDVLPI FAYPHKLGKS
VTGGYVYRGC EYPNLNGLYI FGDFMSGRLM SLRENPETGQ WKYSEVCMGR GQTCAFPGLI
NNYYPYIISF AEDEAGELYF MSTGVPSATA AHGVIYKVID PSRRAPPGKC KIRPAQVKVR
SHLIPFVPKE KFIRTPESTP RPTARAPTKA PRRRRPTAAP PAPTPRPTKP ARPTRRPGAR
KGGGRRRGRP STAVPEPENG SVRLVRPAGL SPGRGRVEVF IGGRWGTVCD DAWDTKAAAV
VCRQLGFAHA VRAAKRAEFG EGRALRILLD DVRCAGSERN LLECAHAGVG THNCKHDEDA
GVECSHQDPN L
