ID   HIPL2_ARATH             Reviewed;         696 AA.
AC   Q94F08; Q9LV15;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2003, sequence version 2.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=HIPL2 protein;
DE   Flags: Precursor;
GN   Name=HIPL2; OrderedLocusNames=At5g62630; ORFNames=MRG21.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT   features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:31-63(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- COFACTOR:
CC       Name=pyrroloquinoline quinone; Xref=ChEBI:CHEBI:58442;
CC         Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- SIMILARITY: Belongs to the PQQ oxidoreductase GdhB family.
CC       {ECO:0000305}.
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DR   EMBL; AB020751; BAA97210.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED97635.1; -; Genomic_DNA.
DR   EMBL; AF386990; AAK62435.1; -; mRNA.
DR   EMBL; AY081545; AAM10107.1; -; mRNA.
DR   RefSeq; NP_201069.1; NM_125658.3.
DR   AlphaFoldDB; Q94F08; -.
DR   SMR; Q94F08; -.
DR   BioGRID; 21627; 1.
DR   IntAct; Q94F08; 1.
DR   STRING; 3702.AT5G62630.1; -.
DR   PaxDb; Q94F08; -.
DR   PRIDE; Q94F08; -.
DR   ProteomicsDB; 230226; -.
DR   EnsemblPlants; AT5G62630.1; AT5G62630.1; AT5G62630.
DR   GeneID; 836384; -.
DR   Gramene; AT5G62630.1; AT5G62630.1; AT5G62630.
DR   KEGG; ath:AT5G62630; -.
DR   Araport; AT5G62630; -.
DR   TAIR; locus:2172224; AT5G62630.
DR   eggNOG; ENOG502QQKP; Eukaryota.
DR   HOGENOM; CLU_024721_0_0_1; -.
DR   InParanoid; Q94F08; -.
DR   OMA; SCCNSKD; -.
DR   OrthoDB; 728630at2759; -.
DR   PhylomeDB; Q94F08; -.
DR   PRO; PR:Q94F08; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q94F08; baseline and differential.
DR   Genevisible; Q94F08; AT.
DR   GO; GO:0031225; C:anchored component of membrane; TAS:TAIR.
DR   GO; GO:0046658; C:anchored component of plasma membrane; IDA:TAIR.
DR   GO; GO:0009536; C:plastid; HDA:TAIR.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.30; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR018143; Folate_rcpt-like.
DR   InterPro; IPR012938; Glc/Sorbosone_DH.
DR   InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR   Pfam; PF03024; Folate_rec; 1.
DR   Pfam; PF07995; GSDH; 1.
DR   SUPFAM; SSF50952; SSF50952; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Oxidoreductase; PQQ; Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..672
FT                   /note="HIPL2 protein"
FT                   /id="PRO_0000025587"
FT   PROPEP          673..696
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000025588"
FT   LIPID           672
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        124
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        339
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        431
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        513
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        519
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        528
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        581
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        651
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        340
FT                   /note="G -> V (in Ref. 3; AAK62435/AAM10107)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        615
FT                   /note="I -> V (in Ref. 3; AAK62435/AAM10107)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   696 AA;  75617 MW;  8581E940070E86CA CRC64;
     MAKTNQAITI CSLLLLLLLS ETTSHLLCSD SKTPVNNNET LQFCDSYKER SCCNSKDDLQ
     LQNRFNSMNI SDSNCSSLLK SILCSKCDEF SGQLFGDDDS SLVPILCNST SQDLCSKLWD
     SCQNISIVSS PFSPTLLGGA TSPSTSSNSS TLTDLWKSQT EFCTAFGGPS QTNNNKTKCF
     NGEPVNRDTS DDDEDDVKTP KGICLEKIGT GSYLNMVAHP DGSNRAFFSN QPGKIWLGTI
     PDQDSGKPME IDESTPFVDI TDQVSFDTQF GMMGMAFHPK FAENGRFFAS FNCDKVKSPG
     CSGRCACNSD VNCDPSKLPK DDGTTPCRYQ TVVSEYTANG TSSSPSTAKI GKASEVRRIF
     TMGLPYSSSH GGQILFGPDG YLYLMTGDGG GVSDTHNFAQ NKKSLLGKIL RLDVDVMPSV
     SEISKLGLWG NYSIPKNNPF QGNENEQPEI WALGLRNPWR CSFDSERPDY FLCADVGKDT
     YEEVDIITMG GNYGWRTYEG PYVFSPLSPF GENVSSDSNL TFPILGYNHS EVNKHEGSAS
     IIGGYFYRSN TDPCSYGTYL YADLYANAMW AAIESPEDSG NFTDSLIPFS CSKDSPMKCT
     AAPGGASSGP ALGYIYSFGQ DNNKDIHLLT SSGVYRIVRP SRCNLACSKE NTTASAGKQN
     PAGSAPPQPL PSSARKLCFS VFLLLSLLMM FLTLLD