HIPL2_MOUSE
ID HIPL2_MOUSE Reviewed; 717 AA.
AC Q9D2G9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=HHIP-like protein 2;
DE Flags: Precursor;
GN Name=Hhipl2; Synonyms=Hhip3, Kiaa1822l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=129, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D2G9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D2G9-2; Sequence=VSP_030459;
CC -!- SIMILARITY: Belongs to the HHIP family. {ECO:0000305}.
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DR EMBL; AK019671; BAB31831.1; -; mRNA.
DR EMBL; BC034362; AAH34362.1; -; mRNA.
DR EMBL; BG175128; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS56664.1; -. [Q9D2G9-1]
DR CCDS; CCDS78765.1; -. [Q9D2G9-2]
DR RefSeq; NP_001294981.1; NM_001308052.1. [Q9D2G9-2]
DR RefSeq; NP_084451.2; NM_030175.5. [Q9D2G9-1]
DR AlphaFoldDB; Q9D2G9; -.
DR SMR; Q9D2G9; -.
DR BioGRID; 219621; 1.
DR STRING; 10090.ENSMUSP00000070719; -.
DR GlyGen; Q9D2G9; 1 site.
DR iPTMnet; Q9D2G9; -.
DR PhosphoSitePlus; Q9D2G9; -.
DR PaxDb; Q9D2G9; -.
DR PRIDE; Q9D2G9; -.
DR Antibodypedia; 53968; 34 antibodies from 11 providers.
DR DNASU; 78772; -.
DR Ensembl; ENSMUST00000065900; ENSMUSP00000070719; ENSMUSG00000053461. [Q9D2G9-1]
DR Ensembl; ENSMUST00000192527; ENSMUSP00000142121; ENSMUSG00000053461. [Q9D2G9-2]
DR GeneID; 78772; -.
DR KEGG; mmu:78772; -.
DR UCSC; uc012bop.1; mouse. [Q9D2G9-1]
DR CTD; 79802; -.
DR MGI; MGI:1926022; Hhipl2.
DR VEuPathDB; HostDB:ENSMUSG00000053461; -.
DR eggNOG; ENOG502QQKP; Eukaryota.
DR GeneTree; ENSGT00940000161139; -.
DR HOGENOM; CLU_012344_2_2_1; -.
DR InParanoid; Q9D2G9; -.
DR OMA; VRFCHLL; -.
DR OrthoDB; 728630at2759; -.
DR PhylomeDB; Q9D2G9; -.
DR TreeFam; TF329059; -.
DR BioGRID-ORCS; 78772; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Hhipl2; mouse.
DR PRO; PR:Q9D2G9; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9D2G9; protein.
DR Bgee; ENSMUSG00000053461; Expressed in animal zygote and 37 other tissues.
DR Genevisible; Q9D2G9; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR018143; Folate_rcpt-like.
DR InterPro; IPR012938; Glc/Sorbosone_DH.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR Pfam; PF03024; Folate_rec; 1.
DR Pfam; PF07995; GSDH; 1.
DR SUPFAM; SSF50952; SSF50952; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..40
FT /evidence="ECO:0000255"
FT CHAIN 41..717
FT /note="HHIP-like protein 2"
FT /id="PRO_0000314965"
FT REGION 642..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..692
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 647
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 203..545
FT /evidence="ECO:0000250"
FT DISULFID 207..551
FT /evidence="ECO:0000250"
FT DISULFID 423..441
FT /evidence="ECO:0000250"
FT DISULFID 508..607
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..220
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030459"
SQ SEQUENCE 717 AA; 79998 MW; 79AD5CF5DA49F688 CRC64;
MLGKHTSPHT VPGHRAPWLS PGIFCLGLPF LLGWVGLLQG HPQCLDYGPP FRPPQHLDFC
SDYDSFGCCD QRKDRRIAAR YWDIMSYFDL KAHELCGGYI KDILCQECSP YAAHLYDAEN
PQTPLRNLPG LCSDYCSAFH RSCHSAISLL TNDRGLQESH GKDGARFCHL LNLPDEDYCF
PNVLRNDQLN RNLGVVAEDQ QGCLQLCLVE VANGLRNPVS MVHAGDGTHR FFVAEQVGVV
WVYLPDGSRL EQPFLDLKSM VLTTPWIGDE RGFLGLAFHP KFRHNRKFYI YYSCLGKRKV
EKIRISEMKV SLSDGNRADP KSERVILEID EPASNHNGGQ LLFGLDGYLY IFTGDGGQAG
DPFGKFGNAQ NKSSLLGKVL RIDVNGADVD GQRYRVPLDN PFVSEPGAHP AVYAYGVRNM
WRCAVDRGDP VTHRGRGRIF CGDVGQNKFE EVDLIVKGGN YGWRAKEGFE CYDKRLCRNA
SLDDILPIYA YGHGVGKSVT GGYVYRGCES PNLNGLYIFG DFMSGRLMAL QEDRKTQKWT
KRDICLGNST CAFPGLISAY SRFIISFAED EAGELYFLAT SYPSAYAPHG SIYKFVDPSR
RAPPGKCKYK PVPVKTKSKK VRFRPLAATV LDLLKEESQK AARKASNATF TSSSDRVASQ
KGSLKKPASS RSSKKTFRRP GTKKKSRVWS PRPQGKRKPN LDSHGVGMRQ AAGRSHP
