ID   HIP_MAIZE               Reviewed;         741 AA.
AC   K7TQE3;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2013, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=HSP-interacting protein {ECO:0000303|PubMed:27541862};
GN   Name=HIP {ECO:0000303|PubMed:27541862};
GN   ORFNames=GRMZM2G023275 {ECO:0000305},
GN   ZEAMMB73_165363 {ECO:0000312|EMBL:AFW57122.1}, Zm.103901;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. B73;
RX   PubMed=19965430; DOI=10.1126/science.1178534;
RA   Schnable P.S., Ware D., Fulton R.S., Stein J.C., Wei F., Pasternak S.,
RA   Liang C., Zhang J., Fulton L., Graves T.A., Minx P., Reily A.D.,
RA   Courtney L., Kruchowski S.S., Tomlinson C., Strong C., Delehaunty K.,
RA   Fronick C., Courtney B., Rock S.M., Belter E., Du F., Kim K., Abbott R.M.,
RA   Cotton M., Levy A., Marchetto P., Ochoa K., Jackson S.M., Gillam B.,
RA   Chen W., Yan L., Higginbotham J., Cardenas M., Waligorski J., Applebaum E.,
RA   Phelps L., Falcone J., Kanchi K., Thane T., Scimone A., Thane N., Henke J.,
RA   Wang T., Ruppert J., Shah N., Rotter K., Hodges J., Ingenthron E.,
RA   Cordes M., Kohlberg S., Sgro J., Delgado B., Mead K., Chinwalla A.,
RA   Leonard S., Crouse K., Collura K., Kudrna D., Currie J., He R.,
RA   Angelova A., Rajasekar S., Mueller T., Lomeli R., Scara G., Ko A.,
RA   Delaney K., Wissotski M., Lopez G., Campos D., Braidotti M., Ashley E.,
RA   Golser W., Kim H., Lee S., Lin J., Dujmic Z., Kim W., Talag J., Zuccolo A.,
RA   Fan C., Sebastian A., Kramer M., Spiegel L., Nascimento L., Zutavern T.,
RA   Miller B., Ambroise C., Muller S., Spooner W., Narechania A., Ren L.,
RA   Wei S., Kumari S., Faga B., Levy M.J., McMahan L., Van Buren P.,
RA   Vaughn M.W., Ying K., Yeh C.-T., Emrich S.J., Jia Y., Kalyanaraman A.,
RA   Hsia A.-P., Barbazuk W.B., Baucom R.S., Brutnell T.P., Carpita N.C.,
RA   Chaparro C., Chia J.-M., Deragon J.-M., Estill J.C., Fu Y., Jeddeloh J.A.,
RA   Han Y., Lee H., Li P., Lisch D.R., Liu S., Liu Z., Nagel D.H., McCann M.C.,
RA   SanMiguel P., Myers A.M., Nettleton D., Nguyen J., Penning B.W.,
RA   Ponnala L., Schneider K.L., Schwartz D.C., Sharma A., Soderlund C.,
RA   Springer N.M., Sun Q., Wang H., Waterman M., Westerman R., Wolfgruber T.K.,
RA   Yang L., Yu Y., Zhang L., Zhou S., Zhu Q., Bennetzen J.L., Dawe R.K.,
RA   Jiang J., Jiang N., Presting G.G., Wessler S.R., Aluru S.,
RA   Martienssen R.A., Clifton S.W., McCombie W.R., Wing R.A., Wilson R.K.;
RT   "The B73 maize genome: complexity, diversity, and dynamics.";
RL   Science 326:1112-1115(2009).
RN   [2]
RP   INTERACTION WITH O1.
RX   PubMed=22892319; DOI=10.1105/tpc.112.101360;
RA   Wang G., Wang F., Wang G., Wang F., Zhang X., Zhong M., Zhang J., Lin D.,
RA   Tang Y., Xu Z., Song R.;
RT   "Opaque1 encodes a myosin XI motor protein that is required for endoplasmic
RT   reticulum motility and protein body formation in maize endosperm.";
RL   Plant Cell 24:3447-3462(2012).
RN   [3]
RP   INTERACTION WITH OP10.
RX   PubMed=27541862; DOI=10.1371/journal.pgen.1006270;
RA   Yao D., Qi W., Li X., Yang Q., Yan S., Ling H., Wang G., Wang G., Song R.;
RT   "Maize opaque10 encodes a cereal-specific protein that is essential for the
RT   proper distribution of zeins in endosperm protein bodies.";
RL   PLoS Genet. 12:E1006270-E1006270(2016).
CC   -!- FUNCTION: Acts as a co-chaperone for HSP90 and is required for proper
CC       folding of the myosin motor domain. {ECO:0000250|UniProtKB:Q8CGY6}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with O1 (PubMed:22892319).
CC       Interacts (via C-terminus) with OP10 (via N-terminus)
CC       (PubMed:27541862). {ECO:0000269|PubMed:22892319,
CC       ECO:0000269|PubMed:27541862}.
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DR   EMBL; CM000786; AFW57122.1; -; Genomic_DNA.
DR   RefSeq; XP_008662790.1; XM_008664568.1.
DR   AlphaFoldDB; K7TQE3; -.
DR   SMR; K7TQE3; -.
DR   STRING; 4577.GRMZM2G023275_P01; -.
DR   PaxDb; K7TQE3; -.
DR   PRIDE; K7TQE3; -.
DR   EnsemblPlants; Zm00001eb414750_T001; Zm00001eb414750_P001; Zm00001eb414750.
DR   GeneID; 103641203; -.
DR   Gramene; Zm00001eb414750_T001; Zm00001eb414750_P001; Zm00001eb414750.
DR   KEGG; zma:103641203; -.
DR   eggNOG; KOG4151; Eukaryota.
DR   HOGENOM; CLU_014258_0_0_1; -.
DR   OMA; DELRWAY; -.
DR   OrthoDB; 260600at2759; -.
DR   Proteomes; UP000007305; Chromosome 10.
DR   ExpressionAtlas; K7TQE3; baseline and differential.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR000270; PB1_dom.
DR   InterPro; IPR044517; PHOX1-4.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR46183; PTHR46183; 1.
DR   Pfam; PF00564; PB1; 1.
DR   SMART; SM00666; PB1; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..741
FT                   /note="HSP-interacting protein"
FT                   /id="PRO_0000438209"
FT   REPEAT          26..59
FT                   /note="TPR 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          65..100
FT                   /note="TPR 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          102..134
FT                   /note="TPR 3"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          285..364
FT                   /note="PB1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT   REPEAT          496..530
FT                   /note="TPR 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          532..557
FT                   /note="TPR 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          558..591
FT                   /note="TPR 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          628..663
FT                   /note="TPR 7"
FT                   /evidence="ECO:0000255"
FT   REGION          168..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..188
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..266
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   741 AA;  84009 MW;  BB34D8528719E870 CRC64;
     MGKPPGARNP AEAEADGDDA VFLELSRELK EEGTRLFNRR DFEGAAFKYD KAVQLLPAGR
     RVEAAHLRAS IAHCYMRMSP AEFHHAIHEC NLALEAVPRY SRALLRRAAC FEALGRPDLA
     WGDIRTVLRW EPGNRAARQI SDRVRTALED KGISVALDVL PEDENEIASA KGEERKKSRN
     KRFDSVAGGR EGENGIALLE SASTEKQAGP RQTNGTGNHQ DHTEDSESNG LEKLEQSTET
     GEKDMGKKRG AHAAGKKPRC GESKQQKHSA VNHCQDNIGA KEEVMKDVKL VFGEDIRCAQ
     MPANCSLPQL REIVQNKFPS LKAFLIKYKD KEEDLVTITL SEELSWASNL AVSQVPIRFY
     VVEVNHVQEL GVDGVRRRPS FATLERNRDI MLDNGTIGHD VEHKHYADDW MVQFAQIFKN
     HVGFSSDAYL DLHDLGLRLH YEAMEDTIQR EEAQEIFEVA ESKFKEMAAL ALFNCGNVHM
     SRARRRPCLA EDPLQEFILE KVNVSYDWAC TEYAKAGAMF EEAVKTKSDF FEGLIALGQQ
     KFEQAKLSWY YALACKINME TEVLELFNHA EDNMEKGMDM WERMETLRLK GLSKPSKEKV
     VLEKMVLEGF VKDISADEAF EQASSIRSHI NILWGTILYE RSVVEFNLGL PSWEESLTVA
     MEKFKIGGAS QADINVIVKN HCANETTQEG LSFKVEEIVQ AWSEMHDAKN WRSGPLYFRL
     QPVFRRRAPK LHHILEHMHY A