HIR1_ASHGO
ID HIR1_ASHGO Reviewed; 825 AA.
AC Q74ZN0;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Protein HIR1;
GN Name=HIR1; OrderedLocusNames=AGR168W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 808.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; AE016820; AAS54658.2; -; Genomic_DNA.
DR RefSeq; NP_986834.2; NM_211896.2.
DR AlphaFoldDB; Q74ZN0; -.
DR STRING; 33169.AAS54658; -.
DR EnsemblFungi; AAS54658; AAS54658; AGOS_AGR168W.
DR GeneID; 4623136; -.
DR KEGG; ago:AGOS_AGR168W; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_0_1; -.
DR InParanoid; Q74ZN0; -.
DR OMA; KRFDVHQ; -.
DR Proteomes; UP000000591; Chromosome VII.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblFungi.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IEA:EnsemblFungi.
DR GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..825
FT /note="Protein HIR1"
FT /id="PRO_0000286401"
FT REPEAT 15..54
FT /note="WD 1"
FT REPEAT 75..114
FT /note="WD 2"
FT REPEAT 132..171
FT /note="WD 3"
FT REPEAT 174..213
FT /note="WD 4"
FT REPEAT 227..270
FT /note="WD 5"
FT REPEAT 309..351
FT /note="WD 6"
FT REPEAT 355..396
FT /note="WD 7"
FT REGION 294..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..588
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 825 AA; 92489 MW; 0CCEDB834C514B64 CRC64;
MKILKLPWLT HQEGQRNYEI YTVDVSSDGQ RVATGGLDGK IRIWSVADIL VFAKPKVSWP
AREEQLRKPL ANMSRHTGSV TALKFSPDNK YLASGSDDKI LLIWEKEEGA VQPLFDMEND
LEHWNVRRRL VAHDNDIQDI CWAPDSSILV TVGLDRSIIV WNGSTFEKIK RFDVHQSHVK
GVVFDPANKY FATASDDRTV KVFRYHKGTD LSFTIEHIIT EPFQGSPLTT YFRRLSWSPD
GQHIAVPNAT NGPVSTVAII SRGNWDTSVS LVGHDQPTEV ACFNPRLFEH NDNHERGEEV
DGASKDNSAA SESSGKRRLK DDDRVDSVIA TAGQDKTLAV WSTSRARPIF VAYDLTSKSV
TDIAWTCDGT ALFLTSLDGR IIVITFEEGE LGKAIPLEQN VEQLHRYGVD KDSLVFPESV
KQLILEDKAR QYKKPYIETT LLESRIGTVK KPNVLNPRPK HAKNDVAVAS IPQAQAPALK
KKEGPLNAAT VQNGKKRVAP TLISTGYARA ATVKFEPRSS IDSDFAGKKE PLKDTSYALA
GKISQPSLPL PRLGVHTLIM GVKERGAERF YVEDEESMDD DAEVADEEDE TKNEHPLTLN
LKTTPERVWK DEPNLRYLEY PGVIPDADVV ICQYGDLDDL HILEIRNGVE RSIQFDREAL
FENPTKILGY HQGERTLEAF LPEVVISCVG SKACQCWALA TASGSLYIYG NHGQLLVPKI
SIGHKVIKLI AWQHFVIAFT ETCLFWIWDI RAMKLVEKEI SVLPVLVQDQ PQCNRVRISR
RILDFRMLAD SHELLVEMSD GASYVWKRAL GCWTDTIGQS TPVTA
