HIR1_ASPFU
ID HIR1_ASPFU Reviewed; 1043 AA.
AC Q4WTC4;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Protein hir1;
GN Name=hir1; ORFNames=AFUA_1G09790;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; AAHF01000004; EAL90308.1; -; Genomic_DNA.
DR RefSeq; XP_752346.1; XM_747253.1.
DR AlphaFoldDB; Q4WTC4; -.
DR SMR; Q4WTC4; -.
DR STRING; 746128.CADAFUBP00000906; -.
DR PRIDE; Q4WTC4; -.
DR EnsemblFungi; EAL90308; EAL90308; AFUA_1G09790.
DR GeneID; 3510468; -.
DR KEGG; afm:AFUA_1G09790; -.
DR VEuPathDB; FungiDB:Afu1g09790; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_1_1; -.
DR InParanoid; Q4WTC4; -.
DR OMA; RGSWDGD; -.
DR OrthoDB; 685536at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0034728; P:nucleosome organization; IEA:EnsemblFungi.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..1043
FT /note="Protein hir1"
FT /id="PRO_0000286402"
FT REPEAT 1..35
FT /note="WD 1"
FT REPEAT 50..89
FT /note="WD 2"
FT REPEAT 111..150
FT /note="WD 3"
FT REPEAT 153..192
FT /note="WD 4"
FT REPEAT 214..257
FT /note="WD 5"
FT REPEAT 260..320
FT /note="WD 6"
FT REPEAT 324..365
FT /note="WD 7"
FT REGION 424..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 112748 MW; 9A838B7C09C5C1F6 CRC64;
MEHEVGMDAD ISDFTLGADG YVRIWSTEAI YNTGNPEYAN KPKQLASMSN HSGTIHTVRF
SPNGKYLASG ADDKIVCIYT LDANPPSHAS TFGSNEAPPV ENWRTIRRLI GHDNDVQDLG
WSYDSSILVS VGLDSKVVVW SGHTFEKLKT LSIHQSHVKG ITFDPANKYF ATASDDRTVR
IFRFTSPSPN STAHDQMNNF VLEHTISAPF QNSPLTAYFR RCSWSPDGMH IAAANAVNGP
VSSVAIINRG SWDGDINLIG HEAPVEVCAF SPRLYSSQPV SKSAVDNQNH AMQNVTVIAC
AGGDKSLSIW ITSNPRPIVV AQEMAAKSIS DLAWSPDGKC LFATALDGTI LAVRFEDGEL
GYPMAMEENE KSLTKFGTNR RGAGIAETTD GLLLEEKSKA GEIKDVEGRM GALMGDGHAT
AESMVNGKTA PLPSNGATPA RGPSPAADTQ KAQPNGTAAT PAAPEPEKPD PYQAKLERLK
QRPTYTKDGK KRIAPLLVSG AGAAESSLPQ ARLMASVSSQ VKADVPQSIV DLSKPFDGLP
KGGLSALLFG NKRKLAQLEG DEDGHVEKRV ALASQNGATP ILANTPDGLL PAQPQPAPTG
QQPTPEFIRP AVTNPCMAIS QLRLAVPKVR SQIVRAIDSN GRPTEPPSAT GEPGKSRADV
VFEARNPSPA SLTGRAVDRE PVRLTLFRGE QPLWQDFLPR TVLLVTGNQS MWSAACEDGS
VYIWSPAGRR LVSALVLEAQ PVILECNGPW ILCISAVGMC YVWNVKHLSS PHPPISLQPV
LDAAIHTLGA HPSAAPAITN ARINSEGRVV VALSNGEGYS YSPSMYTWQR VSEAWWAVGS
QYWNSTEAPV GNLQSAGPQQ DKETTAAVSA GIIPFLERNT TNETLLRGRA YFLQRLIKVL
LSREGYESFE SSVSIAHMEN RLAAALSLGA KEEFRLYLSM YAKRLGAEGL KMKVEELLKG
LIGGLFEEED ETGTGRRLQA NEKEDRNWQE SSDTLCGWPR EVLLKEVILA LGKHRDLQRV
TVPYAKLLGV VDNESEDNDA MET
