ID   HIR1_ASPOR              Reviewed;        1058 AA.
AC   Q2UBU2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Protein HIR1;
GN   Name=HIR1; ORFNames=AO090012000864;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP007161; BAE60973.1; -; Genomic_DNA.
DR   RefSeq; XP_001727812.1; XM_001727760.2.
DR   AlphaFoldDB; Q2UBU2; -.
DR   SMR; Q2UBU2; -.
DR   STRING; 510516.Q2UBU2; -.
DR   PRIDE; Q2UBU2; -.
DR   EnsemblFungi; BAE60973; BAE60973; AO090012000864.
DR   GeneID; 5988286; -.
DR   KEGG; aor:AO090012000864; -.
DR   VEuPathDB; FungiDB:AO090012000864; -.
DR   HOGENOM; CLU_004372_3_1_1; -.
DR   OMA; RGSWDGD; -.
DR   Proteomes; UP000006564; Chromosome 4.
DR   GO; GO:0000417; C:HIR complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034728; P:nucleosome organization; IEA:EnsemblFungi.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..1058
FT                   /note="Protein HIR1"
FT                   /id="PRO_0000286403"
FT   REPEAT          15..54
FT                   /note="WD 1"
FT   REPEAT          69..108
FT                   /note="WD 2"
FT   REPEAT          130..169
FT                   /note="WD 3"
FT   REPEAT          172..211
FT                   /note="WD 4"
FT   REPEAT          233..276
FT                   /note="WD 5"
FT   REPEAT          279..339
FT                   /note="WD 6"
FT   REPEAT          343..384
FT                   /note="WD 7"
FT   REGION          427..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          590..618
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          652..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..477
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1058 AA;  114529 MW;  AC2FC2D94CAD6EA3 CRC64;
     MHIIKPVWLT HGGERKDFEV YSCDVSPDGS RLVTAAGDGY VRIWSTEAIC NTNDPAVASK
     PKQLASMSNH SGTIHTVRFS PNGKYLASGA DDKIVCIYTL DTNPPSHATT FGSNEAPPVE
     NWRTVRRLIG HDNDVQDLGW SYDSSILVSV GLDSKVVVWS GHTFEKLKTI SIHQSHVKGI
     TFDPANKYFA TASDDRTVRI FRFTSPAPNS TAHDQMNNFV LEQTISAPFA NSPLTAYFRR
     CSWSPDGMHI AAANAVNGPV SSVAIINRGS WDGDINLIGH EAPVEVCAFS PRLYASQPVD
     KQAMDNQHGA QNLVTVIACA GGDKSLSIWI TSNPRPIVVA QELAAKSLSD LAWSPDGKCL
     YATALDGTIL AVRFEDGDLG YATAMEENEK SLTKFGTNRK GAGITETPDG LLLEEKSKAG
     EIKGVEGRMG ALMGDDQADN ITNEKPALLP SNAPTPARPS SPAPDAQKSQ PNGTATPSAP
     EPEKPDPYQA KLERLKQRPT YTKDGKKRIA PLLVSGAGAA ESSLPQARLM ASVSNQVKAD
     TPQSIVDLSK PFDGLPKGGL ATLLFGNKRK LAQLEEDDDG HVEKRVALAS QNGATPLLTN
     TPDGLLPARP QPAPTGQQPT PEFIRPAVTN PCMAMSQVRL AVPKVRNQIL RAIDPNGKPT
     EPPSASGESS KSRVDVVFEA RNPSAASLTG RAVDREPVRL TLFRGEQPLW QDFLPRTVLL
     VTGNQSMWAA ACEDGSVYIW TPAGRRLVSA LVLEAQPVIL ECNGPWILCI SAVGMCYVWN
     VKHLSSPHPP VSLQPALDAA IHTLGAHPSA APAITNARIN SEGRIVVAMS NGEGYSYSPS
     MFTWQRISEP WWAVGSQYWN TTEAPVGNLQ TADAQKDKDA KAAVSAGIIP FLERNTTSET
     LLRGRAYFLQ RLIKVLLSRE GYESFESSVS IAHLENRLAA ALSLGAKEEF RLYLSMYAKR
     IGAEGLKMKV EELLKGLIGG LFEEDEAGTA QRLQENEQED RNWRESSETL CGWPREVLLK
     EVILALGKHR DLQRVTVPYA KLLGVVDGES DVGDAMET