ID   HIR1_ASPTN              Reviewed;         999 AA.
AC   Q0CQ54;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Protein hir1;
GN   Name=hir1; ORFNames=ATEG_04180;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR   EMBL; CH476598; EAU35982.1; -; Genomic_DNA.
DR   RefSeq; XP_001213358.1; XM_001213358.1.
DR   AlphaFoldDB; Q0CQ54; -.
DR   SMR; Q0CQ54; -.
DR   STRING; 341663.Q0CQ54; -.
DR   EnsemblFungi; EAU35982; EAU35982; ATEG_04180.
DR   GeneID; 4318578; -.
DR   VEuPathDB; FungiDB:ATEG_04180; -.
DR   eggNOG; KOG0973; Eukaryota.
DR   HOGENOM; CLU_004372_3_1_1; -.
DR   OMA; RGSWDGD; -.
DR   OrthoDB; 685536at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0000417; C:HIR complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034728; P:nucleosome organization; IEA:EnsemblFungi.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR031120; HIR1.
DR   InterPro; IPR011494; Hira.
DR   InterPro; IPR019015; HIRA_B_motif.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13831; PTHR13831; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF09453; HIRA_B; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..999
FT                   /note="Protein hir1"
FT                   /id="PRO_0000286404"
FT   REPEAT          15..54
FT                   /note="WD 1"
FT   REPEAT          69..108
FT                   /note="WD 2"
FT   REPEAT          130..169
FT                   /note="WD 3"
FT   REPEAT          172..211
FT                   /note="WD 4"
FT   REPEAT          233..276
FT                   /note="WD 5"
FT   REPEAT          279..339
FT                   /note="WD 6"
FT   REPEAT          343..384
FT                   /note="WD 7"
FT   REGION          439..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..469
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   999 AA;  107339 MW;  AA6AC51A5225F32F CRC64;
     MHIIKPVWLT HGGKLVVHDS SSSWHGPLTP TLLSTGERKD FEVYSCDVSP DGSRLVTAAG
     DGYVRIWSTE AIRNTDDSSQ KPKQLASMSN HSGTIHTVRF SPNGKYLASG ADDKIVCIYT
     LDANPPSHST FGWSYDSSIL VSVGLDSKVV VWSGHTFEKL KTLSVHQSHV KGITFDPANK
     YFATASDDRT VKIFRFTSPA PNSTAHDQMN NFVLETTISA PFQNSPLTAY FRRCSWSPDG
     MHIAAANAVN GPVSSVAIIN RGSWDGDINL IGHEAPVEVC AFSPRLYSTQ PPNKQTPDNQ
     GQAVTVIACA GGDKSLSIWI TTNPRPIVVA QELAAKSISD LAWSPDGTCL YATALDGTIL
     AVRFEDGDLG YPMAMEENEK SLTKFGTNRR GAGITETTDG LLLEEKSKAG ELKGVEGRMG
     ALMGDGHASA EATVNGKALS SNGAAPAQGT SPTADAQKTQ TNGTTTPAAQ EADKPDPYQA
     KLERLKQRPT YTKDGKKRIA PLLVSGAGAA ESSLPQARLM ASVSSQVKAD TPQSIVDLSK
     PFDGLPKGGL AALLFGNKRK LAQLEGDEDG HVEKRVALAS QNGATPIMAN TPDGLLPAQP
     QPPATGQQQT PEYIRPAVTN PCMAISQLRL AVPKVRSQIV RAIDSTGKPT EPPGASSEAN
     KSRVDLVFEA RNPSPASLTG RAVDREPVRL TLFRGEQPLW QDFLPRTVLL VTGNQSMWAA
     ACEDGSVYIW TPAGRRLVSA LVLEAQPVIL ECNGPWILCI SAVGMCYVWN VKHLSSPHPP
     ISLQPVLDAA VHTLGAHPSS APAITNARIN SEGRVIVALS NGEGYAYSPS MYTWQRMSEA
     WWAVGSQYWN TTEAPVGNLQ STDSQDKDAK AAVSAGIIPF LERNTTNETL LRGRAYFLQR
     LIKVLLSREG YESFESSVSI AHLENRLAAA LSLGAKEEFR LYLSMYAKRI GAEGLKNKVE
     ELLKGLIGGK HRDLQRVTVP YAKLLGVVDE SEAGDAMET