HIR1_CANAL
ID HIR1_CANAL Reviewed; 907 AA.
AC Q5ACW8; A0A1D8PG32;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 2.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Protein HIR1;
GN Name=HIR1; OrderedLocusNames=CAALFM_C200330CA;
GN ORFNames=CaO19.2099, CaO19.9647;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27087.1; -; Genomic_DNA.
DR RefSeq; XP_019330737.1; XM_019475192.1.
DR AlphaFoldDB; Q5ACW8; -.
DR SMR; Q5ACW8; -.
DR STRING; 237561.Q5ACW8; -.
DR PRIDE; Q5ACW8; -.
DR GeneID; 3638796; -.
DR KEGG; cal:CAALFM_C200330CA; -.
DR CGD; CAL0000197832; HIR1.
DR VEuPathDB; FungiDB:C2_00330C_A; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_0_1; -.
DR InParanoid; Q5ACW8; -.
DR OrthoDB; 685536at2759; -.
DR PRO; PR:Q5ACW8; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblFungi.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR GO; GO:0007059; P:chromosome segregation; IMP:CACAO.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IEA:EnsemblFungi.
DR GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF07676; PD40; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..907
FT /note="Protein HIR1"
FT /id="PRO_0000286405"
FT REPEAT 15..54
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 89..128
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 147..186
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 189..228
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 292..346
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 350..391
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REGION 532..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 102369 MW; E074FE2E81CEA60B CRC64;
MQILKIPWFG HKTENKTVEC YAVTINKDGT RLASGGLDGN VKIWDLTTIN VFYKMADQPH
KSKKDSTSTK LEESLPDKSL RRPLCSMSRH NGVVTSLKFS PDGRWLASGS DDKICLIWEK
DNTQIAKSFG TDEHDLEHWT VRKRLVAHDN DIQDICWSPD GNLLVTVGLD RSVIIWNALT
FEKIKRYDIH QSMVKGIVFD PANKFFATAS DDRTVRIFRY YKKLNEYNNY EFQMEHVVVD
PFKKSPLTSY FRRMSWSPDG QHIAVPNATN GPVPSVAIIN RGNWGSDISL IGHEAPVEVC
SFSPTLFQIA DTPANEEIKF QTVVATGGQD RTLAIWSTCN SRPIVVCSDI VDSSITDICW
SPDGETLYFS CLDGSITGVK FGARELGQPV KEDLIDQQLN RYGADRESTI LPESVEQLQL
EEQSKDSRAI SIRRMMPIQE AKPEQTPPIS TPASAAIDIE RLRKQTVTMT KSGKKRVAPL
LVSTSAAPKN VLQKPLEKKR RTKSSSKISQ AAYLLPKMGV QTTVHGIKKK AESMSNDTEV
EENNDNDDIG ENVMANTNSV SDAALKRQRN RRKRKLMELK YPSSFKYISN LPEGLFNNHT
LQNIEINKIY KAHSKHKDIS AEISSSTAVE IDEDLVFSVV FRVFDHMRKE NEVLGQTSGR
IRTTIEVRNG KPWDDDISDR DFDDATKVIV TEEGNDKREY CLFFPFRVQH VLPIILNDVL
KYYVLCSFHG SVQIISADTG SYRCPTFELG ESVVTMRHSQ GYMLVLTSSG LFYSWDLKAM
KVTMTGISIA AILNNYEIGG KIVVSPIVRG LEINPQDGSP LVLLDMTNDI YGYSIDLQCW
VKTVDSWYYG VGADKDLDVV LTGLVKKSKM SYEEDKVTEK IFTYKFDSSN DLEDAMRKRG
QELLDLI
