HIR1_CANGA
ID HIR1_CANGA Reviewed; 840 AA.
AC Q6FVD3;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Protein HIR1;
GN Name=HIR1; OrderedLocusNames=CAGL0E02805g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
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DR EMBL; CR380951; CAG58730.1; -; Genomic_DNA.
DR RefSeq; XP_445811.1; XM_445811.1.
DR AlphaFoldDB; Q6FVD3; -.
DR SMR; Q6FVD3; -.
DR STRING; 5478.XP_445811.1; -.
DR PRIDE; Q6FVD3; -.
DR EnsemblFungi; CAG58730; CAG58730; CAGL0E02805g.
DR GeneID; 2887422; -.
DR KEGG; cgr:CAGL0E02805g; -.
DR CGD; CAL0129108; CAGL0E02805g.
DR VEuPathDB; FungiDB:CAGL0E02805g; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_0_1; -.
DR InParanoid; Q6FVD3; -.
DR OMA; KRFDVHQ; -.
DR Proteomes; UP000002428; Chromosome E.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblFungi.
DR GO; GO:0000417; C:HIR complex; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0031491; F:nucleosome binding; IEA:EnsemblFungi.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:EnsemblFungi.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IEA:EnsemblFungi.
DR GO; GO:1905268; P:negative regulation of chromatin organization; IEA:EnsemblFungi.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IEA:EnsemblFungi.
DR GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR031120; HIR1.
DR InterPro; IPR011494; Hira.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13831; PTHR13831; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..840
FT /note="Protein HIR1"
FT /id="PRO_0000286406"
FT REPEAT 15..54
FT /note="WD 1"
FT REPEAT 72..111
FT /note="WD 2"
FT REPEAT 129..168
FT /note="WD 3"
FT REPEAT 171..210
FT /note="WD 4"
FT REPEAT 224..267
FT /note="WD 5"
FT REPEAT 292..336
FT /note="WD 6"
FT REPEAT 340..381
FT /note="WD 7"
SQ SEQUENCE 840 AA; 94224 MW; 6BE1898D760BA273 CRC64;
MRIVKFPWFS HHEESRDYEI YTVDVSPDGK RVATGGLDGK IRIWSVDALV SAAAGESGVD
RDTHRPLASM SRHTGSVTCV KFSPDGNYLA SGSDDRILLI WAMDEENHGG SFGSEGEKEH
WTVRKRLVAH DNDIQDICWA PDSSILVTVG LDRSVIVWNG LNFERLKRFD VHQSLVKGVI
FDPANKYFAT ASDDRTMRVF RYHKTGEVSF TIEQVIVEPF IASPLTTYFR RLSWSPDGQH
IAVPNATNGP VSSVAIINRG TWDSSISLIG HDAPTEVARF NPRLFKSDVE KKAKNAKDEL
SKDTKNNKKL ESIIATAGQD KSLALWITSR PRPIFVAYDI AQKSITDMAW NPNGNILFVT
SLDSSIVMLM FDANELGMPI PIEGNMEQLH RYGVDKDSFD LPESVNQLLL EDKYGTKKKQ
HELSSSTQST ALERRLEPNQ FQKKINSREI SPLKSTEKVN ILIPKRKKDM KMNKVIVKDG
KKRVAPTLIS TAGLQPTVTN VKEVASSSGK VVKPVLKKTN DINEYSGRLS TPSIPIPRLG
IHTLVMGLKE RGKDKFERGA EVGPDDELRE ASNQITFDGE SYGQDSLMKD EYRMTLNNRL
TKEKVSSNEP YLRYIENTGV IADTDAVLLE CGSIDDFFTL EIRNGVERAI QFDSDALFDN
PTRILGYHEG QRTIEAFIPN VIISGVGSPV SKYWSLATAD GFIYIISYNG QLLIPKINLG
QKVVKQVVCS NYLLVLTERG LFYAWDISAK RSVIKNVSIL PIINNDPVEG NRVRVNKSIR
KFEFEVSEKT VIVHLTNNRS FKWLAYFGCW SEIQELVAPR ETVANILLTE NEIPPQSSSI
